Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots

Study Objective To assess the association between tenofovir diphosphate (TFV‐DP) in dried blood spots (DBS), a measure of cumulative tenofovir‐based antiretroviral (ART) adherence, with medication regimen complexity in persons with human immunodeficiency virus (PWH). Design Prospective clinical cohort (up to three visits over 48 weeks). Setting Academic‐based HIV clinic. Patients PWH receiving tenofovir disoproxil fumarate (TDF)‐based ART. Measurements DBS for TFV‐DP were collected at every study visit. Baseline patient‐level medication regimen complexity index (pMRCI) scores were calculated and categorized into three sub‐scores (disease‐specific [ART], non‐ART, and over‐the‐counter [OTC]). The pMRCI scores were evaluated to assess the association with TFV‐DP in DBS