Clinical outcome of COVID-19 in patients with adult congenital heart disease
AimsPatients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical ou...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2021-08, Vol.107 (15), p.1226-1232 |
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| creator | Schwerzmann, Markus Ruperti-Repilado, Francisco Javier Baumgartner, Helmut Bouma, Berto Bouchardy, Judith Budts, Werner Campens, Laurence Chessa, Massimo del Cerro Marin, Maria Jesús Gabriel, Harald Gallego, Pastora Garcia-Orta, Rocio Gonzalez, Ana Elvira Jensen, Annette Schophuus Ladouceur, Magalie Miranda-Barrio, Berta Morissens, Marielle Pasquet, Agnes Rueda, Joaquín van den Bosch, Annemien E van der Zwaan, Heleen Berdina Tobler, Daniel Greutmann, Matthias |
| description | AimsPatients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.MethodsTwenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.ResultsOf 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).ConclusionsAmong patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome. |
| doi_str_mv | 10.1136/heartjnl-2020-318467 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7944416</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2550591297</sourcerecordid><originalsourceid>FETCH-LOGICAL-b476t-5241cd17dded3a10ecfa3c4940fab6aa271bda826212f088c1379137df44f2923</originalsourceid><addsrcrecordid>eNqNkU9PHSEUxUmjqX_ab9AYEjdupnKBYYZNk-ZVW5OXuLFNd4QBxsfLDDwHxsZvL_rUVFcuCOTyOyfn5iD0BchXACZOV05PeR2GihJKKgYtF80HtA9ctGUEf3fKm9V1JQhr9tBBSmtCCJet-Ij2GBNtLRnso-Vi8MEbPeA4ZxNHh2OPF5d_Ln5UILEPeKOzdyEn_M_nFdZ2HjI2MVy74HNRPabA1ienk_uEdns9JPf56T5Ev8_Prha_quXlz4vF92XV8UbkqqYcjIXGWmeZBuJMr5nhkpNed0Jr2kBndUsFBdqTtjXAGlmO7TnvqaTsEH3b-m7mbnTWlHyTHtRm8qOe7lTUXr3-CX6lruOtaiTnHEQxOHkymOLN7FJWo0_GDYMOLs5JUS4lk4xTUtDjN-g6zlMo6yla16SWQGVTKL6lzBRTmlz_EgaIeqhLPdelHupS27qK7Oj_RV5Ez_0U4HQLdOP6fZb3NGKiAQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2550591297</pqid></control><display><type>article</type><title>Clinical outcome of COVID-19 in patients with adult congenital heart disease</title><source>PubMed Central</source><creator>Schwerzmann, Markus ; Ruperti-Repilado, Francisco Javier ; Baumgartner, Helmut ; Bouma, Berto ; Bouchardy, Judith ; Budts, Werner ; Campens, Laurence ; Chessa, Massimo ; del Cerro Marin, Maria Jesús ; Gabriel, Harald ; Gallego, Pastora ; Garcia-Orta, Rocio ; Gonzalez, Ana Elvira ; Jensen, Annette Schophuus ; Ladouceur, Magalie ; Miranda-Barrio, Berta ; Morissens, Marielle ; Pasquet, Agnes ; Rueda, Joaquín ; van den Bosch, Annemien E ; van der Zwaan, Heleen Berdina ; Tobler, Daniel ; Greutmann, Matthias</creator><creatorcontrib>Schwerzmann, Markus ; Ruperti-Repilado, Francisco Javier ; Baumgartner, Helmut ; Bouma, Berto ; Bouchardy, Judith ; Budts, Werner ; Campens, Laurence ; Chessa, Massimo ; del Cerro Marin, Maria Jesús ; Gabriel, Harald ; Gallego, Pastora ; Garcia-Orta, Rocio ; Gonzalez, Ana Elvira ; Jensen, Annette Schophuus ; Ladouceur, Magalie ; Miranda-Barrio, Berta ; Morissens, Marielle ; Pasquet, Agnes ; Rueda, Joaquín ; van den Bosch, Annemien E ; van der Zwaan, Heleen Berdina ; Tobler, Daniel ; Greutmann, Matthias ; EPOCH</creatorcontrib><description>AimsPatients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.MethodsTwenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.ResultsOf 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).ConclusionsAmong patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2020-318467</identifier><identifier>PMID: 33685931</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Body mass index ; Clinical outcomes ; Congenital diseases ; Congenital Heart Disease ; Coronaviruses ; COVID-19</subject><ispartof>Heart (British Cardiac Society), 2021-08, Vol.107 (15), p.1226-1232</ispartof><rights>Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b476t-5241cd17dded3a10ecfa3c4940fab6aa271bda826212f088c1379137df44f2923</citedby><cites>FETCH-LOGICAL-b476t-5241cd17dded3a10ecfa3c4940fab6aa271bda826212f088c1379137df44f2923</cites><orcidid>0000-0002-4006-8929 ; 0000-0002-9904-0402 ; 0000-0003-2115-5047 ; 0000-0002-5045-2449 ; 0000-0001-7432-4815 ; 0000-0003-4170-6416 ; 0000-0002-0821-3196 ; 0000-0002-0422-9860</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944416/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944416/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33685931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwerzmann, Markus</creatorcontrib><creatorcontrib>Ruperti-Repilado, Francisco Javier</creatorcontrib><creatorcontrib>Baumgartner, Helmut</creatorcontrib><creatorcontrib>Bouma, Berto</creatorcontrib><creatorcontrib>Bouchardy, Judith</creatorcontrib><creatorcontrib>Budts, Werner</creatorcontrib><creatorcontrib>Campens, Laurence</creatorcontrib><creatorcontrib>Chessa, Massimo</creatorcontrib><creatorcontrib>del Cerro Marin, Maria Jesús</creatorcontrib><creatorcontrib>Gabriel, Harald</creatorcontrib><creatorcontrib>Gallego, Pastora</creatorcontrib><creatorcontrib>Garcia-Orta, Rocio</creatorcontrib><creatorcontrib>Gonzalez, Ana Elvira</creatorcontrib><creatorcontrib>Jensen, Annette Schophuus</creatorcontrib><creatorcontrib>Ladouceur, Magalie</creatorcontrib><creatorcontrib>Miranda-Barrio, Berta</creatorcontrib><creatorcontrib>Morissens, Marielle</creatorcontrib><creatorcontrib>Pasquet, Agnes</creatorcontrib><creatorcontrib>Rueda, Joaquín</creatorcontrib><creatorcontrib>van den Bosch, Annemien E</creatorcontrib><creatorcontrib>van der Zwaan, Heleen Berdina</creatorcontrib><creatorcontrib>Tobler, Daniel</creatorcontrib><creatorcontrib>Greutmann, Matthias</creatorcontrib><creatorcontrib>EPOCH</creatorcontrib><title>Clinical outcome of COVID-19 in patients with adult congenital heart disease</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>AimsPatients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.MethodsTwenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.ResultsOf 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).ConclusionsAmong patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.</description><subject>Body mass index</subject><subject>Clinical outcomes</subject><subject>Congenital diseases</subject><subject>Congenital Heart Disease</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9PHSEUxUmjqX_ab9AYEjdupnKBYYZNk-ZVW5OXuLFNd4QBxsfLDDwHxsZvL_rUVFcuCOTyOyfn5iD0BchXACZOV05PeR2GihJKKgYtF80HtA9ctGUEf3fKm9V1JQhr9tBBSmtCCJet-Ij2GBNtLRnso-Vi8MEbPeA4ZxNHh2OPF5d_Ln5UILEPeKOzdyEn_M_nFdZ2HjI2MVy74HNRPabA1ienk_uEdns9JPf56T5Ev8_Prha_quXlz4vF92XV8UbkqqYcjIXGWmeZBuJMr5nhkpNed0Jr2kBndUsFBdqTtjXAGlmO7TnvqaTsEH3b-m7mbnTWlHyTHtRm8qOe7lTUXr3-CX6lruOtaiTnHEQxOHkymOLN7FJWo0_GDYMOLs5JUS4lk4xTUtDjN-g6zlMo6yla16SWQGVTKL6lzBRTmlz_EgaIeqhLPdelHupS27qK7Oj_RV5Ez_0U4HQLdOP6fZb3NGKiAQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Schwerzmann, 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Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4006-8929</orcidid><orcidid>https://orcid.org/0000-0002-9904-0402</orcidid><orcidid>https://orcid.org/0000-0003-2115-5047</orcidid><orcidid>https://orcid.org/0000-0002-5045-2449</orcidid><orcidid>https://orcid.org/0000-0001-7432-4815</orcidid><orcidid>https://orcid.org/0000-0003-4170-6416</orcidid><orcidid>https://orcid.org/0000-0002-0821-3196</orcidid><orcidid>https://orcid.org/0000-0002-0422-9860</orcidid></search><sort><creationdate>20210801</creationdate><title>Clinical outcome of COVID-19 in patients with adult congenital heart disease</title><author>Schwerzmann, Markus ; Ruperti-Repilado, Francisco Javier ; Baumgartner, Helmut ; Bouma, Berto ; Bouchardy, Judith ; Budts, Werner ; Campens, Laurence ; Chessa, Massimo ; del Cerro Marin, Maria Jesús ; Gabriel, Harald ; Gallego, Pastora ; Garcia-Orta, Rocio ; Gonzalez, Ana Elvira ; Jensen, Annette Schophuus ; Ladouceur, Magalie ; Miranda-Barrio, Berta ; Morissens, Marielle ; Pasquet, Agnes ; Rueda, Joaquín ; van den Bosch, Annemien E ; van der Zwaan, Heleen Berdina ; Tobler, Daniel ; Greutmann, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b476t-5241cd17dded3a10ecfa3c4940fab6aa271bda826212f088c1379137df44f2923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body mass index</topic><topic>Clinical outcomes</topic><topic>Congenital diseases</topic><topic>Congenital Heart Disease</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwerzmann, Markus</creatorcontrib><creatorcontrib>Ruperti-Repilado, Francisco Javier</creatorcontrib><creatorcontrib>Baumgartner, Helmut</creatorcontrib><creatorcontrib>Bouma, Berto</creatorcontrib><creatorcontrib>Bouchardy, Judith</creatorcontrib><creatorcontrib>Budts, Werner</creatorcontrib><creatorcontrib>Campens, Laurence</creatorcontrib><creatorcontrib>Chessa, Massimo</creatorcontrib><creatorcontrib>del Cerro Marin, Maria Jesús</creatorcontrib><creatorcontrib>Gabriel, Harald</creatorcontrib><creatorcontrib>Gallego, Pastora</creatorcontrib><creatorcontrib>Garcia-Orta, Rocio</creatorcontrib><creatorcontrib>Gonzalez, Ana Elvira</creatorcontrib><creatorcontrib>Jensen, Annette Schophuus</creatorcontrib><creatorcontrib>Ladouceur, Magalie</creatorcontrib><creatorcontrib>Miranda-Barrio, Berta</creatorcontrib><creatorcontrib>Morissens, Marielle</creatorcontrib><creatorcontrib>Pasquet, Agnes</creatorcontrib><creatorcontrib>Rueda, Joaquín</creatorcontrib><creatorcontrib>van den Bosch, Annemien E</creatorcontrib><creatorcontrib>van der Zwaan, Heleen Berdina</creatorcontrib><creatorcontrib>Tobler, Daniel</creatorcontrib><creatorcontrib>Greutmann, Matthias</creatorcontrib><creatorcontrib>EPOCH</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwerzmann, Markus</au><au>Ruperti-Repilado, Francisco Javier</au><au>Baumgartner, Helmut</au><au>Bouma, Berto</au><au>Bouchardy, Judith</au><au>Budts, Werner</au><au>Campens, Laurence</au><au>Chessa, Massimo</au><au>del Cerro Marin, Maria Jesús</au><au>Gabriel, Harald</au><au>Gallego, Pastora</au><au>Garcia-Orta, Rocio</au><au>Gonzalez, Ana Elvira</au><au>Jensen, Annette Schophuus</au><au>Ladouceur, Magalie</au><au>Miranda-Barrio, Berta</au><au>Morissens, Marielle</au><au>Pasquet, Agnes</au><au>Rueda, Joaquín</au><au>van den Bosch, Annemien E</au><au>van der Zwaan, Heleen Berdina</au><au>Tobler, Daniel</au><au>Greutmann, Matthias</au><aucorp>EPOCH</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcome of COVID-19 in patients with adult congenital heart disease</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>107</volume><issue>15</issue><spage>1226</spage><epage>1232</epage><pages>1226-1232</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>AimsPatients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated with a poor COVID-19 outcome. Risk estimation in ACHD is currently based on expert opinion. The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD.MethodsTwenty-five ACHD centres in nine European countries participated in the study. Consecutive patients with ACHD diagnosed with COVID-19 presenting to one of the participating centres between 27 March and 6 June 2020 were included. A complicated disease course was defined as hospitalisation for COVID-19 requiring non-invasive or invasive ventilation and/or inotropic support, or a fatal outcome.ResultsOf 105 patients with a mean age of 38±13 years (58% women), 13 had a complicated disease course, of whom 5 died. In univariable analysis, age (OR 1.3, 95% CI 1.1 to 1.7, per 5 years), ≥2 comorbidities (OR 7.1, 95% CI 2.1 to 24.5), body mass index of >25 kg/m2 (OR 7.2, 95% CI 1.9 to 28.3) and cyanotic heart disease (OR 13.2, 95% CI 2.5 to 68.4) were associated with a complicated disease course. In a multivariable logistic regression model, cyanotic heart disease was the most important predictor (OR 60.0, 95% CI 7.6 to 474.0).ConclusionsAmong patients with ACHD, general risk factors (age, obesity and multiple comorbidities) are associated with an increased risk of complicated COVID-19 course. Congenital cardiac defects at particularly high risk were cyanotic lesions, including unrepaired cyanotic defects or Eisenmenger syndrome.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>33685931</pmid><doi>10.1136/heartjnl-2020-318467</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4006-8929</orcidid><orcidid>https://orcid.org/0000-0002-9904-0402</orcidid><orcidid>https://orcid.org/0000-0003-2115-5047</orcidid><orcidid>https://orcid.org/0000-0002-5045-2449</orcidid><orcidid>https://orcid.org/0000-0001-7432-4815</orcidid><orcidid>https://orcid.org/0000-0003-4170-6416</orcidid><orcidid>https://orcid.org/0000-0002-0821-3196</orcidid><orcidid>https://orcid.org/0000-0002-0422-9860</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2021-08, Vol.107 (15), p.1226-1232 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7944416 |
| source | PubMed Central |
| subjects | Body mass index Clinical outcomes Congenital diseases Congenital Heart Disease Coronaviruses COVID-19 |
| title | Clinical outcome of COVID-19 in patients with adult congenital heart disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T01%3A52%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20outcome%20of%20COVID-19%20in%20patients%20with%20adult%20congenital%20heart%20disease&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Schwerzmann,%20Markus&rft.aucorp=EPOCH&rft.date=2021-08-01&rft.volume=107&rft.issue=15&rft.spage=1226&rft.epage=1232&rft.pages=1226-1232&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2020-318467&rft_dat=%3Cproquest_pubme%3E2550591297%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2550591297&rft_id=info:pmid/33685931&rfr_iscdi=true |