Pre‐existing influenza‐specific nasal IgA or nasal viral infection does not affect live attenuated influenza vaccine immunogenicity in children

Summary The United Kingdom has a national immunization programme which includes annual influenza vaccination in school‐aged children, using live attenuated influenza vaccine (LAIV). LAIV is given annually, and it is unclear whether repeat administration can affect immunogenicity. Because LAIV is del...

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Veröffentlicht in:	Clinical and experimental immunology 2021-04, Vol.204 (1), p.125-133
Hauptverfasser:	Cole, M. E., Kundu, R., Abdulla, A. F., Andrews, N., Hoschler, K., Southern, J., Jackson, D., Miller, E., Zambon, M., Turner, P. J., Tregoning, J. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adolescent Antibodies Antibodies, Viral - immunology Child Children Female Humans IgA Immunization Immunogenicity Immunogenicity, Vaccine - immunology Immunoglobulin A Immunoglobulin A - immunology Immunoglobulin G Immunoglobulin G - immunology Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology LAIV Male mucosal Nasal Cavity - immunology Nasal Cavity - virology Original Polymerase chain reaction Respiratory tract diseases Reverse transcription RNA viruses schoolchildren Vaccination Vaccination - methods Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Virus Shedding - immunology
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