Focal Adhesion Kinase Inhibitor Inhibits the Oxidative Damage Induced by Central Venous Catheter via Abolishing Focal Adhesion Kinase-Protein Kinase B Pathway Activation

The vascular injury induced by central venous catheter (CVC) indwelling is the basis for the occurrence and development of CVC-related complications, such as phlebitis, venous thrombosis, and catheter-related infections. Focal adhesion kinase (FAK) and FAK-protein kinase B (AKT) signaling pathway ar...

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Veröffentlicht in:	BioMed research international 2021, Vol.2021 (1), p.6685493
Hauptverfasser:	Wang, Yanru, Lin, Sulan, Jiang, Ping, Song, Yunlin, Zhao, Yanjie, Zheng, Yujian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion AKT protein Antibodies Atria Blood circulation disorders Blood vessels Care and treatment Catheterization Catheters Causes of Cell culture Cell viability Cellular signal transduction Central venous catheters Complications Complications and side effects Damage Development and progression Enzyme inhibitors Focal adhesion kinase Health aspects Iatrogenic diseases Jugular vein Kinases Medical instruments Medical research Medicine, Experimental Oxidative stress Penicillin Phlebitis Phosphorylation Physiological aspects Protein kinases Protein tyrosine kinase Proteins Rabbits Risk factors Signal transduction Thromboembolism Thrombosis Trauma Vascular tissue Veins Veins & arteries
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