Combinatorial BRD4 and AURKA inhibition is synergistic against preclinical models of Ewing sarcoma

Background Ewing sarcoma (ES), a bone cancer affecting children, adolescents, and young adults, is driven by the EWS‐FLI1 fusion protein in the majority of cases, but the mechanisms of tumorigenesis are still being elucidated. Consequentially, therapeutic advances have been limited in the last 25 ye...

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Veröffentlicht in:	Cancer reports 2019-06, Vol.2 (3), p.n/a
Hauptverfasser:	Tomino, Laura, Bopp, Emily, Felgenhauer, Joshua, Selich‐Anderson, Julia, Shah, Nilay
Format:	Artikel
Sprache:	eng
Schlagworte:	AURKA BRD4 Ewing sarcoma Original synergy
Online-Zugang:	Volltext
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