Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial

IMPORTANCE: Meta-analyses of randomized clinical trials have indicated that improved hypertension control reduces the risk for cognitive impairment and dementia. However, it is unclear to what extent pathways reflective of Alzheimer disease (AD) pathology are affected by hypertension control. OBJECT...

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Veröffentlicht in:	Archives of neurology (Chicago) 2021-05, Vol.78 (5), p.568-577
Hauptverfasser:	Nasrallah, Ilya M, Gaussoin, Sarah A, Pomponio, Raymond, Dolui, Sudipto, Erus, Guray, Wright, Clinton B, Launer, Lenore J, Detre, John A, Wolk, David A, Davatzikos, Christos, Williamson, Jeff D, Pajewski, Nicholas M, Bryan, R. Nick
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Anisotropy Antihypertensive Agents - therapeutic use Atrophy Biomarkers Biomarkers - analysis Blood flow Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Brain Brain - drug effects Brain - pathology Brain - physiopathology Cerebral blood flow Cingulum Clinical trials Cognitive ability Cognitive Dysfunction - complications Cognitive Dysfunction - drug therapy Cognitive Dysfunction - pathology Comments Dementia disorders Diabetes mellitus Female Health services Hippocampus Humans Hypertension Hypertension - drug therapy Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Middle Aged Neurodegenerative diseases Neuroimaging Online First Original Investigation Randomization Resonance Risk Factors Risk management Secondary analysis Statistical analysis
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