S‐nitrosoglutathione reductase maintains mitochondrial homeostasis by promoting clearance of damaged mitochondria in porcine preimplantation embryos

Objectives S‐nitrosoglutathione reductase (GSNOR), a protein denitrosylase, protects the mitochondria from mitochondrial nitrosative stress. Mammalian preimplantation embryos are mitochondria‐rich, but the effects of GSNOR on mitochondrial function in preimplantation embryos are not well‐studied. In...

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Veröffentlicht in:	Cell proliferation 2021-03, Vol.54 (3), p.e12990-n/a
Hauptverfasser:	Niu, Ying‐Jie, Zhou, Dongjie, Cui, Xiang‐Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidoreductases - drug effects Animals Apoptosis Arginine Autophagy Autophagy - drug effects Blastocyst - metabolism Cell death Clearances Damage accumulation Depolarization DNA damage Double-stranded RNA Embryos Fluorescent indicators GSNOR Homeostasis Homeostasis - drug effects Immunofluorescence Laboratory animals Mammals Membrane potential Mitochondria Mitochondria - drug effects Mitochondria - metabolism NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide - metabolism Original Oxidative stress Oxidative Stress - drug effects Oxidoreductases - metabolism Phagocytosis Phosphorylation Physiology Polyvinyl alcohol porcine preimplantation embryos Protein S Proteins Quality control Reactive oxygen species Reactive Oxygen Species - metabolism Reductases Reverse transcription S-Nitrosoglutathione - pharmacology Supplements Swine S‐nitrosylation
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