Acyl‐CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis

Aims Acyl‐CoA synthetase long chain family member 4 (ACSL4) is closely related to tumor genesis and development in certain tissues. However, the function of ACSL4 in early brain injury (EBI) caused by subarachnoid hemorrhage (SAH) is unclear. In this study, we investigated the expression patterns an...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2021-04, Vol.27 (4), p.449-463
Hauptverfasser:	Qu, Xiao‐feng, Liang, Tian‐yu, Wu, De‐gang, Lai, Nian‐sheng, Deng, Ru‐ming, Ma, Chao, Li, Xiang, Li, Hai‐ying, Liu, Yi‐zhi, Shen, Hai‐tao, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl‐CoA synthetase long chain family member 4 Aneurysms Animals Apoptosis Blood-brain barrier Brain Injuries - metabolism Brain Injuries - pathology Brain injury Coenzyme A Ligases - biosynthesis Cognitive ability early brain injury Edema Enzymes Experiments Fatty acids Ferroptosis Ferroptosis - physiology Labeling Male Maze Learning - physiology Metabolism Original Oxidative stress Permeability Rats Rats, Sprague-Dawley Rodents Stroke Subarachnoid hemorrhage Subarachnoid Hemorrhage - metabolism Subarachnoid Hemorrhage - pathology Traumatic brain injury
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