Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias

Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been identified as a key disease mechanism in mouse models, no suitable in vitro system has been reported to analyze the pathology in humans. Here, we...

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Veröffentlicht in:	Stem cell reports 2021-03, Vol.16 (3), p.610-625
Hauptverfasser:	Pretemer, Yann, Kawai, Shunsuke, Nagata, Sanae, Nishio, Megumi, Watanabe, Makoto, Tamaki, Sakura, Alev, Cantas, Yamanaka, Yoshihiro, Xue, Jing-Yi, Wang, Zheng, Fukiage, Kenichi, Tsukanaka, Masako, Futami, Tohru, Ikegawa, Shiro, Toguchida, Junya
Format:	Artikel
Sprache:	eng
Schlagworte:	chondrodysplasia COL10A1 iPSC MATN3 unfolded protein response
Online-Zugang:	Volltext
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