CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown. Here, we determined the comprehensive mitochondrial proteome of cortical astrocytes and neu...

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Veröffentlicht in:	Cell stem cell 2021-03, Vol.28 (3), p.524-534.e7
Hauptverfasser:	Russo, Gianluca L., Sonsalla, Giovanna, Natarajan, Poornemaa, Breunig, Christopher T., Bulli, Giorgia, Merl-Pham, Juliane, Schmitt, Sabine, Giehrl-Schwab, Jessica, Giesert, Florian, Jastroch, Martin, Zischka, Hans, Wurst, Wolfgang, Stricker, Stefan H., Hauck, Stefanie M., Masserdotti, Giacomo, Götz, Magdalena
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant Cell & Tissue Engineering Cell Biology CRISPR-a direct reprogramming Life Sciences & Biomedicine metabolism mitochondria proteome Science & Technology Short
Online-Zugang:	Volltext
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