Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms

Some cancers originate from a single mutation event in a single cell. Blood cancers known as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is acquired by a hematopoietic stem cell (HSC). However, when the mutation first occurs in individuals and how it affects t...

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Veröffentlicht in:	Cell stem cell 2021-03, Vol.28 (3), p.514-523.e9
Hauptverfasser:	Van Egeren, Debra, Escabi, Javier, Nguyen, Maximilian, Liu, Shichen, Reilly, Christopher R., Patel, Sachin, Kamaz, Baransel, Kalyva, Maria, DeAngelo, Daniel J., Galinsky, Ilene, Wadleigh, Martha, Winer, Eric S., Luskin, Marlise R., Stone, Richard M., Garcia, Jacqueline S., Hobbs, Gabriela S., Camargo, Fernando D., Michor, Franziska, Mullally, Ann, Cortes-Ciriano, Isidro, Hormoz, Sahand
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult blood cancer Cell Differentiation Child Hematopoietic Stem Cells Humans JAK2 Janus Kinase 2 - genetics lineage tree Middle Aged Mutation - genetics Myeloproliferative Disorders - genetics myeloproliferative neoplasm Neoplasms Short single cell sequencing stem cell dynamics Young Adult
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