Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure

Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane-bound glycoproteins and proteoglycans that covers the lumen of endothelial cells, functions as a barrier to circulating...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2020-12, Vol.295 (52), p.18614-18624
Hauptverfasser:	Ko, Kenta, Suzuki, Takehiro, Ishikawa, Ryota, Hattori, Natsuko, Ito, Risako, Umehara, Kenta, Furihata, Tomomi, Dohmae, Naoshi, Linhardt, Robert J., Igarashi, Kazuei, Toida, Toshihiko, Higashi, Kyohei
Format:	Artikel
Sprache:	eng
Schlagworte:	acrolein Acrolein - pharmacology Amino Acid Sequence Animals Brain Ischemia - etiology Brain Ischemia - metabolism Brain Ischemia - pathology chondroitin sulfate Chondroitin Sulfates - metabolism Disease Models, Animal Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Glucuronidase - chemistry Glucuronidase - genetics Glucuronidase - metabolism Glycobiology and Extracellular Matrices glycocalyx Glycocalyx - metabolism Glycocalyx - pathology heparan sulfate heparanase Heparitin Sulfate - metabolism Humans hyaluronan hyaluronidase Hyaluronoglucosaminidase - metabolism ischemic stroke Ischemic Stroke - etiology Ischemic Stroke - metabolism Ischemic Stroke - pathology Male Mice Mice, Inbred C57BL Photochemistry Protein Conformation stroke
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!