Development of a novel mammalian display system for selection of antibodies against membrane proteins

Reliable, specific polyclonal and monoclonal antibodies are important tools in research and medicine. However, the discovery of antibodies against their targets in their native forms is difficult. Here, we present a novel method for discovery of antibodies against membrane proteins in their native c...

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Veröffentlicht in:	The Journal of biological chemistry 2020-12, Vol.295 (52), p.18436-18448
Hauptverfasser:	Robertson, Nathan, Lopez-Anton, Nancy, Gurjar, Shalom A., Khalique, Hena, Khalaf, Zainab, Clerkin, Siobhan, Leydon, Vaughan R., Parker-Manuel, Richard, Raeside, Alexander, Payne, Tom, Jones, Tim D., Seymour, Len, Cawood, Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - isolation & purification antibody antibody engineering chimeric antigen receptor T cells (CAR-T) Cricetinae Cricetulus epithelial cell adhesion molecule (EpCAM) Epithelial Cell Adhesion Molecule - immunology Gene Library Humans immunotherapy Jurkat Cells mammalian display membrane protein Membrane Proteins - immunology Methods and Resources Protein Binding Receptors, Chimeric Antigen - immunology Single-Chain Antibodies - immunology therapeutic antibody discovery
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