microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai
Background Alveolar echinococcosis (AE) is caused by parasitic infection by Echinococcus multilocularis. Its diagnosis is usually based on clinical symptoms, ultrasound, and other imaging methods. MicroRNAs (miRNAs) play important roles in disease processes and can exist in a highly stable cell-free...
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| Veröffentlicht in: | BMC infectious diseases 2021-03, Vol.21 (1), p.246-246, Article 246 |
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| description | Background Alveolar echinococcosis (AE) is caused by parasitic infection by Echinococcus multilocularis. Its diagnosis is usually based on clinical symptoms, ultrasound, and other imaging methods. MicroRNAs (miRNAs) play important roles in disease processes and can exist in a highly stable cell-free form in body fluids. It is important to identify specific, sensitive diagnostic markers for early diagnosis and evaluation of AE. In this study, we examined hsa-miR-125b-5p as a potential plasma biomarker of E. multilocularis infection. Methods Plasma samples from patients with AE and healthy individuals were screened for the presence of five miRNAs using miRNA chips. We used quantitative polymerase chain reaction to measure miRNA expression levels in plasma and liver tissue samples from patients with AE. Results hsa-miR-125b-5p was stably upregulated in the plasma and liver tissue samples from patients with AE. Conclusions The results suggest that hsa-miR-125b-5p may be a promising biomarker for early, non-invasive diagnosis of AE. |
| doi_str_mv | 10.1186/s12879-021-05940-z |
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Its diagnosis is usually based on clinical symptoms, ultrasound, and other imaging methods. MicroRNAs (miRNAs) play important roles in disease processes and can exist in a highly stable cell-free form in body fluids. It is important to identify specific, sensitive diagnostic markers for early diagnosis and evaluation of AE. In this study, we examined hsa-miR-125b-5p as a potential plasma biomarker of E. multilocularis infection. Methods Plasma samples from patients with AE and healthy individuals were screened for the presence of five miRNAs using miRNA chips. We used quantitative polymerase chain reaction to measure miRNA expression levels in plasma and liver tissue samples from patients with AE. Results hsa-miR-125b-5p was stably upregulated in the plasma and liver tissue samples from patients with AE. Conclusions The results suggest that hsa-miR-125b-5p may be a promising biomarker for early, non-invasive diagnosis of AE.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-021-05940-z</identifier><identifier>PMID: 33678159</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Alveolar echinococcosis ; Alveoli ; Animals ; Biological markers ; Biomarker ; Biomarkers ; Biomarkers - blood ; Body fluids ; Cells, Cultured ; Cysts ; Diagnosis ; Early Diagnosis ; Echinococcosis ; Echinococcosis - blood ; Echinococcosis - diagnosis ; Echinococcosis - genetics ; Echinococcus multilocularis ; Echinococcus multilocularis - genetics ; Female ; Free form ; Gene expression ; Health aspects ; Hospitals ; hsa-miR-125b-5p ; Humans ; Identification and classification ; Infections ; Infectious Diseases ; Life Sciences & Biomedicine ; Liver ; Male ; MicroRNA ; MicroRNAs ; MicroRNAs - blood ; miRNA ; Molecular diagnostic techniques ; Parasitic diseases ; Plasma ; Polymerase chain reaction ; Ribonucleic acid ; RNA ; Science & Technology ; Signs and symptoms ; Software ; Tropical diseases ; Ultrasonic testing ; Ultrasound ; Up-Regulation</subject><ispartof>BMC infectious diseases, 2021-03, Vol.21 (1), p.246-246, Article 246</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000626079600001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c631t-4bbdc7fb54080131fae851d33e27e858e4000e15993c2a564edb126c7008e963</citedby><cites>FETCH-LOGICAL-c631t-4bbdc7fb54080131fae851d33e27e858e4000e15993c2a564edb126c7008e963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938541/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938541/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33678159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deping, Cao</creatorcontrib><creatorcontrib>Bofan, Jiang</creatorcontrib><creatorcontrib>Yaogang, Zhang</creatorcontrib><creatorcontrib>Mingquan, Pang</creatorcontrib><title>microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai</title><title>BMC infectious diseases</title><addtitle>BMC INFECT DIS</addtitle><addtitle>BMC Infect Dis</addtitle><description>Background Alveolar echinococcosis (AE) is caused by parasitic infection by Echinococcus multilocularis. Its diagnosis is usually based on clinical symptoms, ultrasound, and other imaging methods. MicroRNAs (miRNAs) play important roles in disease processes and can exist in a highly stable cell-free form in body fluids. It is important to identify specific, sensitive diagnostic markers for early diagnosis and evaluation of AE. In this study, we examined hsa-miR-125b-5p as a potential plasma biomarker of E. multilocularis infection. Methods Plasma samples from patients with AE and healthy individuals were screened for the presence of five miRNAs using miRNA chips. We used quantitative polymerase chain reaction to measure miRNA expression levels in plasma and liver tissue samples from patients with AE. Results hsa-miR-125b-5p was stably upregulated in the plasma and liver tissue samples from patients with AE. Conclusions The results suggest that hsa-miR-125b-5p may be a promising biomarker for early, non-invasive diagnosis of AE.</description><subject>Alveolar echinococcosis</subject><subject>Alveoli</subject><subject>Animals</subject><subject>Biological markers</subject><subject>Biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body fluids</subject><subject>Cells, Cultured</subject><subject>Cysts</subject><subject>Diagnosis</subject><subject>Early Diagnosis</subject><subject>Echinococcosis</subject><subject>Echinococcosis - blood</subject><subject>Echinococcosis - diagnosis</subject><subject>Echinococcosis - genetics</subject><subject>Echinococcus multilocularis</subject><subject>Echinococcus multilocularis - genetics</subject><subject>Female</subject><subject>Free form</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>hsa-miR-125b-5p</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver</subject><subject>Male</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>miRNA</subject><subject>Molecular diagnostic techniques</subject><subject>Parasitic diseases</subject><subject>Plasma</subject><subject>Polymerase chain reaction</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Science & Technology</subject><subject>Signs and symptoms</subject><subject>Software</subject><subject>Tropical diseases</subject><subject>Ultrasonic testing</subject><subject>Ultrasound</subject><subject>Up-Regulation</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk9v1DAQxSMEoqXwBTggS1xAKMV2nNi-IFUr_lSqqCgVV8txJrsuWXuxkwV65oMz2y2lizhUOXjk_N6bzOQVxVNGDxlTzevMuJK6pJyVtNaClpf3in0mJCt5VYn7t-q94lHOF5Qyqbh-WOxVVSMVq_V-8WvpXYpnH49Kxuu2rFfEZ2LJKsWlzz7MSYhrGMhqsHlpSevj0qavkEgfE7HDGuJgEwG38CG66FzMKPeBrOzoIYyZ9GhExgWQHCc8UthYr31wQGJPPmGHhfWPiwe9HTI8uT4PivN3b89nH8qT0_fHs6OT0jUVG0vRtp2TfVsLqiirWG9B1ayrKuASKwWCUgo4lq4ct3UjoGsZb5ykVIFuqoPieGvbRXthVsnjLD9NtN5cXcQ0NzaN3g1gWimYk03biYoLqcE6Lq0WIHijrOoZer3Zeq2mdgmdw2GTHXZMd98EvzDzuDZSV6oWG4MX1wYpfpsgjwYX7mAYbIA4ZcOFVloz_HmIPv8HvYhTCrgpw2vKm5pqpf5Sc4sD-NBH7Os2puaoqWsuONWbtof_ofDpAJMQA_Qe73cEL3cEyIzwY5zbKWdz_Pns7uzpl12Wb1mMX84J-pvdMWo28TbbeBuMt7mKt7lE0bPbW7-R_MkzAq-2wHdoY58dhtDBDYbxaHhDpW6woptvUHenZ37EUMcwi1MYq9_cLRQ4</recordid><startdate>20210307</startdate><enddate>20210307</enddate><creator>Deping, Cao</creator><creator>Bofan, Jiang</creator><creator>Yaogang, Zhang</creator><creator>Mingquan, Pang</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210307</creationdate><title>microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai</title><author>Deping, Cao ; Bofan, Jiang ; Yaogang, Zhang ; Mingquan, Pang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c631t-4bbdc7fb54080131fae851d33e27e858e4000e15993c2a564edb126c7008e963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alveolar echinococcosis</topic><topic>Alveoli</topic><topic>Animals</topic><topic>Biological markers</topic><topic>Biomarker</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body fluids</topic><topic>Cells, Cultured</topic><topic>Cysts</topic><topic>Diagnosis</topic><topic>Early Diagnosis</topic><topic>Echinococcosis</topic><topic>Echinococcosis - blood</topic><topic>Echinococcosis - diagnosis</topic><topic>Echinococcosis - genetics</topic><topic>Echinococcus multilocularis</topic><topic>Echinococcus multilocularis - genetics</topic><topic>Female</topic><topic>Free form</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>hsa-miR-125b-5p</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver</topic><topic>Male</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>miRNA</topic><topic>Molecular diagnostic techniques</topic><topic>Parasitic diseases</topic><topic>Plasma</topic><topic>Polymerase chain reaction</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Science & Technology</topic><topic>Signs and symptoms</topic><topic>Software</topic><topic>Tropical diseases</topic><topic>Ultrasonic testing</topic><topic>Ultrasound</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deping, Cao</creatorcontrib><creatorcontrib>Bofan, Jiang</creatorcontrib><creatorcontrib>Yaogang, Zhang</creatorcontrib><creatorcontrib>Mingquan, Pang</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deping, Cao</au><au>Bofan, Jiang</au><au>Yaogang, Zhang</au><au>Mingquan, Pang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai</atitle><jtitle>BMC infectious diseases</jtitle><stitle>BMC INFECT DIS</stitle><addtitle>BMC Infect Dis</addtitle><date>2021-03-07</date><risdate>2021</risdate><volume>21</volume><issue>1</issue><spage>246</spage><epage>246</epage><pages>246-246</pages><artnum>246</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract>Background Alveolar echinococcosis (AE) is caused by parasitic infection by Echinococcus multilocularis. Its diagnosis is usually based on clinical symptoms, ultrasound, and other imaging methods. MicroRNAs (miRNAs) play important roles in disease processes and can exist in a highly stable cell-free form in body fluids. It is important to identify specific, sensitive diagnostic markers for early diagnosis and evaluation of AE. In this study, we examined hsa-miR-125b-5p as a potential plasma biomarker of E. multilocularis infection. Methods Plasma samples from patients with AE and healthy individuals were screened for the presence of five miRNAs using miRNA chips. We used quantitative polymerase chain reaction to measure miRNA expression levels in plasma and liver tissue samples from patients with AE. Results hsa-miR-125b-5p was stably upregulated in the plasma and liver tissue samples from patients with AE. Conclusions The results suggest that hsa-miR-125b-5p may be a promising biomarker for early, non-invasive diagnosis of AE.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>33678159</pmid><doi>10.1186/s12879-021-05940-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alveolar echinococcosis Alveoli Animals Biological markers Biomarker Biomarkers Biomarkers - blood Body fluids Cells, Cultured Cysts Diagnosis Early Diagnosis Echinococcosis Echinococcosis - blood Echinococcosis - diagnosis Echinococcosis - genetics Echinococcus multilocularis Echinococcus multilocularis - genetics Female Free form Gene expression Health aspects Hospitals hsa-miR-125b-5p Humans Identification and classification Infections Infectious Diseases Life Sciences & Biomedicine Liver Male MicroRNA MicroRNAs MicroRNAs - blood miRNA Molecular diagnostic techniques Parasitic diseases Plasma Polymerase chain reaction Ribonucleic acid RNA Science & Technology Signs and symptoms Software Tropical diseases Ultrasonic testing Ultrasound Up-Regulation |
| title | microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai |
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