Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site

A vaccine which is effective against the HIV virus is considered to be the best solution to the ongoing global HIV/AIDS epidemic. In the past thirty years, numerous attempts to develop an effective vaccine have been made with little or no success, due, in large part, to the high mutability of the vi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-03, Vol.118 (9), p.1-12
Hauptverfasser:	Conti, Simone, Kaczorowski, Kevin J., Song, Ge, Porter, Katelyn, Andrabi, Raiees, Burton, Dennis R., Chakraborty, Arup K., Karplus, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - biosynthesis AIDS Vaccines - chemistry AIDS Vaccines - genetics Amino Acid Sequence Antigens, Viral - chemistry Antigens, Viral - genetics Antigens, Viral - immunology Binding Sites Biological Sciences Broadly Neutralizing Antibodies - biosynthesis Broadly Neutralizing Antibodies - chemistry CD4-Positive T-Lymphocytes - chemistry CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Crystallography, X-Ray Epitopes - chemistry Epitopes - genetics Epitopes - immunology HIV Antibodies - biosynthesis HIV Antibodies - chemistry HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - metabolism HIV Envelope Protein gp160 - chemistry HIV Envelope Protein gp160 - genetics HIV Envelope Protein gp160 - metabolism HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - metabolism HIV Infections - immunology HIV Infections - prevention & control HIV Infections - virology HIV-1 - chemistry HIV-1 - genetics HIV-1 - immunology Humans Models, Molecular Mutation Physical Sciences Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Engineering - methods Protein Interaction Domains and Motifs
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