Genetic profile of adult T‐cell leukemia/lymphoma in Okinawa: Association with prognosis, ethnicity, and HTLV‐1 strains

Genetic alterations in adult T‐cell leukemia/lymphoma (ATLL), a T‐cell malignancy associated with HTLV‐1, and their clinical impacts, especially from the perspective of viral strains, are not fully elucidated. We employed targeted next‐generation sequencing and single nucleotide polymorphism array f...

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Veröffentlicht in:	Cancer science 2021-03, Vol.112 (3), p.1300-1309
Hauptverfasser:	Sakihama, Shugo, Morichika, Kazuho, Saito, Rumiko, Miyara, Megumi, Miyagi, Takashi, Hayashi, Masaki, Uchihara, Junnosuke, Tomoyose, Takeaki, Ohshiro, Kazuiku, Nakayama, Shingo, Nakachi, Sawako, Morishima, Satoko, Sakai, Kazuko, Nishio, Kazuto, Masuzaki, Hiroaki, Fukushima, Takuya, Karube, Kennosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adult T‐cell leukemia/lymphoma Aged Aged, 80 and over Biomarkers, Tumor - genetics Cancer CCR7 protein Deoxyribonucleic acid DNA DNA Copy Number Variations Ethnicity Ethnicity - genetics Female Follow-Up Studies GATA-3 protein Gene polymorphism Gene Products, tax - genetics Genes Genetic analysis Genetic Profile Genotyping Techniques geographical mutation heterogeneity High-Throughput Nucleotide Sequencing HTLV-I Infections - genetics HTLV-I Infections - pathology HTLV-I Infections - virology Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - isolation & purification human T‐cell leukemia virus type I Humans integrated clinico‐genetic analysis Japan Kaplan-Meier Estimate Leukemia Leukemia-Lymphoma, Adult T-Cell - genetics Leukemia-Lymphoma, Adult T-Cell - mortality Leukemia-Lymphoma, Adult T-Cell - pathology Leukemia-Lymphoma, Adult T-Cell - virology Lymphoma Male Malignancy Medical prognosis Middle Aged Mutation Original Phylogenetics Polymorphism Polymorphism, Single Nucleotide Prognosis RhoA protein Single-nucleotide polymorphism Statistical analysis T cell receptors tax subgroup Therapeutic applications
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