Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

SIRT5 is a member of the sirtuin family of NAD + -dependent protein lysine deacylases implicated in a variety of physiological processes. SIRT5 removes negatively charged malonyl, succinyl, and glutaryl groups from lysine residues and thereby regulates multiple enzymes involved in cellular metabolis...

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Veröffentlicht in:	Oncogene 2021-03, Vol.40 (9), p.1644-1658
Hauptverfasser:	Abril, Yashira L. Negrón, Fernandez, Irma R., Hong, Jun Young, Chiang, Ying-Ling, Kutateladze, Dennis A., Zhao, Qingjie, Yang, Min, Hu, Jing, Sadhukhan, Sushabhan, Li, Bo, He, Bin, Remick, Brenna, Bai, Jessica Jingyi, Mullmann, James, Wang, Fangyu, Maymi, Viviana, Dhawan, Ravi, Auwerx, Johan, Southard, Teresa, Cerione, Richard A., Lin, Hening, Weiss, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/458 631/67/2327 64 64/60 82/1 82/51 96/106 Animal models Apoptosis Breast cancer Care and treatment Cell Biology Cell culture Development and progression Enzymes Gene expression Genetic aspects Genetic engineering Genetic transformation Health aspects Human Genetics Internal Medicine Lysine Mammary gland Medicine Medicine & Public Health NAD Oncology Oxidative stress Phenotypes Transferases Tumor cell lines Tumorigenesis Tumors Xenografts
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