Extraction of mRNA from Stalled Ribosomes by the Ski Complex

The evolutionarily conserved Ski2-Ski3-Ski8 (Ski) complex containing the 3′→5′ RNA helicase Ski2 binds to 80S ribosomes near the mRNA entrance and facilitates 3′→5′ exosomal degradation of mRNA during ribosome-associated mRNA surveillance pathways. Here, we assayed Ski’s activity using an in vitro r...

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Veröffentlicht in:	Molecular cell 2020-03, Vol.77 (6), p.1340-1349.e6
Hauptverfasser:	Zinoviev, Alexandra, Ayupov, Rustam K., Abaeva, Irina S., Hellen, Christopher U.T., Pestova, Tatyana V.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - genetics Endonucleases - metabolism Exosomes - genetics Exosomes - metabolism GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans mRNA surveillance No-Go decay Nuclear Proteins - genetics Nuclear Proteins - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism ribosome-associated quality control Ribosomes - genetics Ribosomes - metabolism RNA exosome RNA Stability RNA, Messenger - genetics RNA, Messenger - isolation & purification RNA, Messenger - metabolism Ski complex Ski2 helicase
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