HDAC inhibitors suppress the proliferation, migration and invasiveness of human head and neck squamous cell carcinoma cells via p63‑mediated tight junction molecules and p21‑mediated growth arrest

In human head and neck squamous cell carcinoma (HNSCC), the invasion and metastatic properties of cancer cells are promoted by junctional adhesion molecule‑A (JAM‑A) and claudin‑1; these are epithelial tight junction molecules regulated by histone deacetylases (HDACs) and transcription factor p63. H...

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Veröffentlicht in:	Oncology reports 2021-04, Vol.45 (4), p.1, Article 46
Hauptverfasser:	Kakiuchi, Akito, Kakuki, Takuya, Ohwada, Kizuku, Kurose, Makoto, Kondoh, Atsushi, Obata, Kazufumi, Nomura, Kazuaki, Miyata, Ryo, Kaneko, Yakuto, Konno, Takumi, Kohno, Takayuki, Himi, Tetsuo, Takano, Ken-Ichi, Kojima, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Cancer Care and treatment Cell cycle Cell growth Colorectal cancer Epidermal growth factor Ethylenediaminetetraacetic acid Gene expression Growth Head & neck cancer Medical prognosis Metastasis Penicillin Pharmaceutical industry Proteins Scientific equipment and supplies industry Squamous cell carcinoma Tubulins
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