Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

The ability to monitor anti-tumor CD8+ T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA and TCR sequencing to detect and characterize "tumor-matching" (TM) CD8+ T cells in the blood of mice with MC38 tumors or melanoma patients using...

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Veröffentlicht in:	The Journal of experimental medicine 2021-04, Vol.218 (4)
Hauptverfasser:	Pauken, Kristen E, Shahid, Osmaan, Lagattuta, Kaitlyn A, Mahuron, Kelly M, Luber, Jacob M, Lowe, Margaret M, Huang, Linglin, Delaney, Conor, Long, Jaclyn M, Fung, Megan E, Newcomer, Kathleen, Tsai, Katy K, Chow, Melissa, Guinn, Samantha, Kuchroo, Juhi R, Burke, Kelly P, Schenkel, Jason M, Rosenblum, Michael D, Daud, Adil I, Sharpe, Arlene H, Singer, Meromit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - pathology Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Colonic Neoplasms - immunology Colonic Neoplasms - pathology Female Humans Melanoma - blood Melanoma - immunology Mice Mice, Inbred C57BL Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Single-Cell Analysis - methods Skin Neoplasms - blood Skin Neoplasms - immunology Transcriptome Tumor Immunology
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