Roles of Krüppel‐like factor 5 in kidney disease
Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in many diseases, including, cancer, cardiovascular disease a...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2021-03, Vol.25 (5), p.2342-2355 |
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| creator | Li, Jia Liu, Liang Zhou, Wen‐Qian Cai, Lu Xu, Zhong‐Gao Rane, Madhavi J. |
| description | Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in many diseases, including, cancer, cardiovascular disease and gastrointestinal disorders. An important role for KLF5 in the kidney was recently reported, such that KLF5 regulated podocyte apoptosis, renal cell proliferation, tubulointerstitial inflammation and renal fibrosis. In this review, we have summarized the available information in the literature with a brief description on how transcriptional, post‐transcriptional and post‐translational modifications of KLF5 modulate its function in a variety of organs including the kidney with a focus of its importance on the pathogenesis of various kidney diseases. Furthermore, we also have outlined the current and possible mechanisms of KLF5 activation in kidney diseases. These studies suggest a need for more systemic investigations, particularly for generation of animal models with renal cell‐specific deletion or overexpression of KLF5 gene to examine direct contributions of KLF5 to various kidney diseases. This will promote further experimentation in the development of therapies to prevent or treat various kidney diseases. |
| doi_str_mv | 10.1111/jcmm.16332 |
| format | Article |
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KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in many diseases, including, cancer, cardiovascular disease and gastrointestinal disorders. An important role for KLF5 in the kidney was recently reported, such that KLF5 regulated podocyte apoptosis, renal cell proliferation, tubulointerstitial inflammation and renal fibrosis. In this review, we have summarized the available information in the literature with a brief description on how transcriptional, post‐transcriptional and post‐translational modifications of KLF5 modulate its function in a variety of organs including the kidney with a focus of its importance on the pathogenesis of various kidney diseases. Furthermore, we also have outlined the current and possible mechanisms of KLF5 activation in kidney diseases. These studies suggest a need for more systemic investigations, particularly for generation of animal models with renal cell‐specific deletion or overexpression of KLF5 gene to examine direct contributions of KLF5 to various kidney diseases. This will promote further experimentation in the development of therapies to prevent or treat various kidney diseases.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.16332</identifier><identifier>PMID: 33523554</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Amino acids ; Animal models ; Apoptosis ; Cardiovascular diseases ; Cell culture ; Cell growth ; Cell proliferation ; Chromosomes ; Clonal deletion ; Colon ; Cyclin-dependent kinases ; Deoxyribonucleic acid ; diabetes ; DNA ; DNA methylation ; Fibrosis ; Gastrointestinal diseases ; Gene deletion ; Gene expression ; Inflammation ; kidney disease ; Kidney diseases ; Kinases ; Krüppel‐like factor 5 ; Krüppel‐like factors ; Lipids ; Localization ; Metabolism ; MicroRNAs ; Pathogenesis ; Phosphorylation ; Protein expression ; Proteins ; Review ; Reviews ; Small intestine ; Transcription factors</subject><ispartof>Journal of cellular and molecular medicine, 2021-03, Vol.25 (5), p.2342-2355</ispartof><rights>2021 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-f706d6de63c4fd38aff159aceaf7189b7dfd0c42ef674a126e7eee16bf88fd7a3</citedby><cites>FETCH-LOGICAL-c4762-f706d6de63c4fd38aff159aceaf7189b7dfd0c42ef674a126e7eee16bf88fd7a3</cites><orcidid>0000-0003-3048-1135 ; 0000-0001-8287-7145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933973/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933973/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11561,27923,27924,45573,45574,46051,46475,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33523554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Liu, Liang</creatorcontrib><creatorcontrib>Zhou, Wen‐Qian</creatorcontrib><creatorcontrib>Cai, Lu</creatorcontrib><creatorcontrib>Xu, Zhong‐Gao</creatorcontrib><creatorcontrib>Rane, Madhavi J.</creatorcontrib><title>Roles of Krüppel‐like factor 5 in kidney disease</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in many diseases, including, cancer, cardiovascular disease and gastrointestinal disorders. An important role for KLF5 in the kidney was recently reported, such that KLF5 regulated podocyte apoptosis, renal cell proliferation, tubulointerstitial inflammation and renal fibrosis. In this review, we have summarized the available information in the literature with a brief description on how transcriptional, post‐transcriptional and post‐translational modifications of KLF5 modulate its function in a variety of organs including the kidney with a focus of its importance on the pathogenesis of various kidney diseases. Furthermore, we also have outlined the current and possible mechanisms of KLF5 activation in kidney diseases. These studies suggest a need for more systemic investigations, particularly for generation of animal models with renal cell‐specific deletion or overexpression of KLF5 gene to examine direct contributions of KLF5 to various kidney diseases. This will promote further experimentation in the development of therapies to prevent or treat various kidney diseases.</description><subject>Amino acids</subject><subject>Animal models</subject><subject>Apoptosis</subject><subject>Cardiovascular diseases</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Chromosomes</subject><subject>Clonal deletion</subject><subject>Colon</subject><subject>Cyclin-dependent kinases</subject><subject>Deoxyribonucleic acid</subject><subject>diabetes</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Fibrosis</subject><subject>Gastrointestinal diseases</subject><subject>Gene deletion</subject><subject>Gene expression</subject><subject>Inflammation</subject><subject>kidney disease</subject><subject>Kidney diseases</subject><subject>Kinases</subject><subject>Krüppel‐like factor 5</subject><subject>Krüppel‐like factors</subject><subject>Lipids</subject><subject>Localization</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>Pathogenesis</subject><subject>Phosphorylation</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Review</subject><subject>Reviews</subject><subject>Small intestine</subject><subject>Transcription 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expression</topic><topic>Inflammation</topic><topic>kidney disease</topic><topic>Kidney diseases</topic><topic>Kinases</topic><topic>Krüppel‐like factor 5</topic><topic>Krüppel‐like factors</topic><topic>Lipids</topic><topic>Localization</topic><topic>Metabolism</topic><topic>MicroRNAs</topic><topic>Pathogenesis</topic><topic>Phosphorylation</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Review</topic><topic>Reviews</topic><topic>Small intestine</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Liu, Liang</creatorcontrib><creatorcontrib>Zhou, Wen‐Qian</creatorcontrib><creatorcontrib>Cai, Lu</creatorcontrib><creatorcontrib>Xu, Zhong‐Gao</creatorcontrib><creatorcontrib>Rane, Madhavi J.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free 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Med</addtitle><date>2021-03</date><risdate>2021</risdate><volume>25</volume><issue>5</issue><spage>2342</spage><epage>2355</epage><pages>2342-2355</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in many diseases, including, cancer, cardiovascular disease and gastrointestinal disorders. An important role for KLF5 in the kidney was recently reported, such that KLF5 regulated podocyte apoptosis, renal cell proliferation, tubulointerstitial inflammation and renal fibrosis. In this review, we have summarized the available information in the literature with a brief description on how transcriptional, post‐transcriptional and post‐translational modifications of KLF5 modulate its function in a variety of organs including the kidney with a focus of its importance on the pathogenesis of various kidney diseases. Furthermore, we also have outlined the current and possible mechanisms of KLF5 activation in kidney diseases. These studies suggest a need for more systemic investigations, particularly for generation of animal models with renal cell‐specific deletion or overexpression of KLF5 gene to examine direct contributions of KLF5 to various kidney diseases. This will promote further experimentation in the development of therapies to prevent or treat various kidney diseases.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>33523554</pmid><doi>10.1111/jcmm.16332</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-3048-1135</orcidid><orcidid>https://orcid.org/0000-0001-8287-7145</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Animal models Apoptosis Cardiovascular diseases Cell culture Cell growth Cell proliferation Chromosomes Clonal deletion Colon Cyclin-dependent kinases Deoxyribonucleic acid diabetes DNA DNA methylation Fibrosis Gastrointestinal diseases Gene deletion Gene expression Inflammation kidney disease Kidney diseases Kinases Krüppel‐like factor 5 Krüppel‐like factors Lipids Localization Metabolism MicroRNAs Pathogenesis Phosphorylation Protein expression Proteins Review Reviews Small intestine Transcription factors |
| title | Roles of Krüppel‐like factor 5 in kidney disease |
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