The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF). These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an increased export of lactate. We identify the mitochondrial pyruvate carrier (MPC) and the cellular lactate exporter mono...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2021-03, Vol.33 (3), p.629-648.e10
Hauptverfasser:	Cluntun, Ahmad A., Badolia, Rachit, Lettlova, Sandra, Parnell, K. Mark, Shankar, Thirupura S., Diakos, Nikolaos A., Olson, Kristofor A., Taleb, Iosif, Tatum, Sean M., Berg, Jordan A., Cunningham, Corey N., Van Ry, Tyler, Bott, Alex J., Krokidi, Aspasia Thodou, Fogarty, Sarah, Skedros, Sophia, Swiatek, Wojciech I., Yu, Xuejing, Luo, Bai, Merx, Shannon, Navankasattusas, Sutip, Cox, James E., Ducker, Gregory S., Holland, William L., McKellar, Stephen H., Rutter, Jared, Drakos, Stavros G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anion Transport Proteins - antagonists & inhibitors Anion Transport Proteins - genetics Anion Transport Proteins - metabolism cardiac metabolism Cardiomegaly - chemically induced Cardiomegaly - complications Cardiomegaly - pathology heart failure Heart Failure - etiology Heart Failure - pathology Heart-Assist Devices Humans hypertrophy lactate Lactic Acid - metabolism LVAD MCT4 Membrane Potential, Mitochondrial Mice Mice, Inbred C57BL Mice, Knockout mitochondria Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - antagonists & inhibitors Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Monocarboxylic Acid Transporters - antagonists & inhibitors Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism MPC Muscle Proteins - antagonists & inhibitors Muscle Proteins - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism pyruvate Pyruvic Acid - metabolism Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - metabolism VB124 Ventricular Function, Left - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!