Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a...
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| Veröffentlicht in: | Molecular neurobiology 2021-04, Vol.58 (4), p.1782-1791 |
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| creator | Toval, Angel Garrigos, Daniel Kutsenko, Yevheniy Popović, Miroljub Do-Couto, Bruno Ribeiro Morales-Delgado, Nicanor Tseng, Kuei Y. Ferran, José Luis |
| description | Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy physical and cognitive development in youth athletes. The central dopamine system is of great interest because of its role in regulating motor behavior through the activation of D1 and D2 receptors. Thus, the aim of the present study is to determine whether D1 or D2 receptor signaling contributes to modulate the exercise capacity during adolescence and if this modulation takes place through the striatum. To test this, we used a rodent model of forced running wheel that we implemented recently to assess the exercise capacity. Briefly, rats were exposed to an 8-day period of habituation in the running wheel before assessing their locomotor performance in response to an incremental exercise test, in which the speed was gradually increased until exhaustion. We found that systemic administration of D1-like (SCH23390) and/or D2-like (raclopride) receptor antagonists prior to the incremental test reduced the duration of forced running in a dose-dependent manner. Similarly, locomotor activity in the open field was decreased by the dopamine antagonists. Interestingly, this was not the case following intrastriatal infusion of an effective dose of SCH23390, which decreased motor performance during the incremental test without disrupting the behavioral response in the open field. Surprisingly, intrastriatal delivery of raclopride failed to impact the duration of forced running. Altogether, these results indicate that the level of locomotor response to incremental loads of forced running in adolescent rats is dopamine dependent and mechanistically linked to the activation of striatal D1 and extra-striatal D2 receptors. |
| doi_str_mv | 10.1007/s12035-020-02252-2 |
| format | Article |
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However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy physical and cognitive development in youth athletes. The central dopamine system is of great interest because of its role in regulating motor behavior through the activation of D1 and D2 receptors. Thus, the aim of the present study is to determine whether D1 or D2 receptor signaling contributes to modulate the exercise capacity during adolescence and if this modulation takes place through the striatum. To test this, we used a rodent model of forced running wheel that we implemented recently to assess the exercise capacity. Briefly, rats were exposed to an 8-day period of habituation in the running wheel before assessing their locomotor performance in response to an incremental exercise test, in which the speed was gradually increased until exhaustion. We found that systemic administration of D1-like (SCH23390) and/or D2-like (raclopride) receptor antagonists prior to the incremental test reduced the duration of forced running in a dose-dependent manner. Similarly, locomotor activity in the open field was decreased by the dopamine antagonists. Interestingly, this was not the case following intrastriatal infusion of an effective dose of SCH23390, which decreased motor performance during the incremental test without disrupting the behavioral response in the open field. Surprisingly, intrastriatal delivery of raclopride failed to impact the duration of forced running. Altogether, these results indicate that the level of locomotor response to incremental loads of forced running in adolescent rats is dopamine dependent and mechanistically linked to the activation of striatal D1 and extra-striatal D2 receptors.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-020-02252-2</identifier><identifier>PMID: 33394335</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescents ; Aging - physiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Child development ; Cognitive ability ; Corpus Striatum - metabolism ; Critical period ; Dopamine ; Dopamine - metabolism ; Dopamine D1 receptors ; Dopamine D2 Receptor Antagonists - pharmacology ; Dopamine D2 receptors ; Habituation ; Habituation, Psychophysiologic ; Locomotor activity ; Male ; Motor Activity ; Motor task performance ; Neostriatum ; Neurobiology ; Neurology ; Neurosciences ; Open Field Test ; Physical Conditioning, Animal ; Physical training ; Raclopride ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1 - antagonists & inhibitors ; Receptors, Dopamine D1 - metabolism ; Receptors, Dopamine D2 - metabolism ; Running ; Teenagers ; Wheel running</subject><ispartof>Molecular neurobiology, 2021-04, Vol.58 (4), p.1782-1791</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy physical and cognitive development in youth athletes. The central dopamine system is of great interest because of its role in regulating motor behavior through the activation of D1 and D2 receptors. Thus, the aim of the present study is to determine whether D1 or D2 receptor signaling contributes to modulate the exercise capacity during adolescence and if this modulation takes place through the striatum. To test this, we used a rodent model of forced running wheel that we implemented recently to assess the exercise capacity. Briefly, rats were exposed to an 8-day period of habituation in the running wheel before assessing their locomotor performance in response to an incremental exercise test, in which the speed was gradually increased until exhaustion. We found that systemic administration of D1-like (SCH23390) and/or D2-like (raclopride) receptor antagonists prior to the incremental test reduced the duration of forced running in a dose-dependent manner. Similarly, locomotor activity in the open field was decreased by the dopamine antagonists. Interestingly, this was not the case following intrastriatal infusion of an effective dose of SCH23390, which decreased motor performance during the incremental test without disrupting the behavioral response in the open field. Surprisingly, intrastriatal delivery of raclopride failed to impact the duration of forced running. Altogether, these results indicate that the level of locomotor response to incremental loads of forced running in adolescent rats is dopamine dependent and mechanistically linked to the activation of striatal D1 and extra-striatal D2 receptors.</description><subject>Adolescents</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Child development</subject><subject>Cognitive ability</subject><subject>Corpus Striatum - metabolism</subject><subject>Critical period</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine D1 receptors</subject><subject>Dopamine D2 Receptor Antagonists - pharmacology</subject><subject>Dopamine D2 receptors</subject><subject>Habituation</subject><subject>Habituation, Psychophysiologic</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Motor Activity</subject><subject>Motor task performance</subject><subject>Neostriatum</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Open Field Test</subject><subject>Physical Conditioning, Animal</subject><subject>Physical training</subject><subject>Raclopride</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D1 - antagonists & inhibitors</subject><subject>Receptors, Dopamine D1 - metabolism</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Running</subject><subject>Teenagers</subject><subject>Wheel running</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1vFCEYx4nR2O3qF_BgSLx4mcrrMHgwafpiTdpoVj0ThoGVZga2wBj9Av3csm67Wg8eCIHn9_yflz8ALzA6wgiJNxkTRHmDCKqHcNKQR2CBOZcNxh15DBaok7QRLesOwGHO16hSGImn4IBSKhmlfAFuT-NGTz7YtPYGXsVhHnXxMcDo4HlMxg5wNYfgwxp-ssnFNOlgLPQBHg9xtNnYUOBKl_wWrup7m_a5JK-LHuEphjoM8OxHSbrJ-18C72vClTV2U2LKz8ATp8dsn9_dS_D1_OzLyUVz-fH9h5Pjy8YwwUrDhRHUWNOzzgnEZOt421LsOGE9s4OlrRgcRT2XuGdt33FCuTOIY9lS45igS_Bup7uZ-8kO2-6THtUm-Umnnypqrx5Ggv-m1vG7EpISWde5BK_vBFK8mW0uavJ1CeOog41zVoQJjmSLO1TRV_-g13FOoY5XKdkSUTlSKbKjTIo5J-v2zWCktjarnc2q2qx-26y2SS__HmOfcu9rBegOyDUU1jb9qf0f2V9jk7OW</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Toval, Angel</creator><creator>Garrigos, Daniel</creator><creator>Kutsenko, Yevheniy</creator><creator>Popović, Miroljub</creator><creator>Do-Couto, Bruno Ribeiro</creator><creator>Morales-Delgado, Nicanor</creator><creator>Tseng, Kuei Y.</creator><creator>Ferran, José Luis</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3413-9452</orcidid></search><sort><creationdate>20210401</creationdate><title>Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors</title><author>Toval, Angel ; Garrigos, Daniel ; Kutsenko, Yevheniy ; Popović, Miroljub ; Do-Couto, Bruno Ribeiro ; Morales-Delgado, Nicanor ; Tseng, Kuei Y. ; Ferran, José Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-57c73cecb48f70496f56631f524b4ede367df30b591b46b85235fc051963cf473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescents</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Child development</topic><topic>Cognitive ability</topic><topic>Corpus Striatum - metabolism</topic><topic>Critical period</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine D1 receptors</topic><topic>Dopamine D2 Receptor Antagonists - pharmacology</topic><topic>Dopamine D2 receptors</topic><topic>Habituation</topic><topic>Habituation, Psychophysiologic</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Motor Activity</topic><topic>Motor task performance</topic><topic>Neostriatum</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Open Field Test</topic><topic>Physical Conditioning, Animal</topic><topic>Physical training</topic><topic>Raclopride</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Dopamine D1 - antagonists & inhibitors</topic><topic>Receptors, Dopamine D1 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toval, Angel</au><au>Garrigos, Daniel</au><au>Kutsenko, Yevheniy</au><au>Popović, Miroljub</au><au>Do-Couto, Bruno Ribeiro</au><au>Morales-Delgado, Nicanor</au><au>Tseng, Kuei Y.</au><au>Ferran, José Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>58</volume><issue>4</issue><spage>1782</spage><epage>1791</epage><pages>1782-1791</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy physical and cognitive development in youth athletes. The central dopamine system is of great interest because of its role in regulating motor behavior through the activation of D1 and D2 receptors. Thus, the aim of the present study is to determine whether D1 or D2 receptor signaling contributes to modulate the exercise capacity during adolescence and if this modulation takes place through the striatum. To test this, we used a rodent model of forced running wheel that we implemented recently to assess the exercise capacity. Briefly, rats were exposed to an 8-day period of habituation in the running wheel before assessing their locomotor performance in response to an incremental exercise test, in which the speed was gradually increased until exhaustion. We found that systemic administration of D1-like (SCH23390) and/or D2-like (raclopride) receptor antagonists prior to the incremental test reduced the duration of forced running in a dose-dependent manner. Similarly, locomotor activity in the open field was decreased by the dopamine antagonists. Interestingly, this was not the case following intrastriatal infusion of an effective dose of SCH23390, which decreased motor performance during the incremental test without disrupting the behavioral response in the open field. Surprisingly, intrastriatal delivery of raclopride failed to impact the duration of forced running. Altogether, these results indicate that the level of locomotor response to incremental loads of forced running in adolescent rats is dopamine dependent and mechanistically linked to the activation of striatal D1 and extra-striatal D2 receptors.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33394335</pmid><doi>10.1007/s12035-020-02252-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3413-9452</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular neurobiology, 2021-04, Vol.58 (4), p.1782-1791 |
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| subjects | Adolescents Aging - physiology Animals Biomedical and Life Sciences Biomedicine Cell Biology Child development Cognitive ability Corpus Striatum - metabolism Critical period Dopamine Dopamine - metabolism Dopamine D1 receptors Dopamine D2 Receptor Antagonists - pharmacology Dopamine D2 receptors Habituation Habituation, Psychophysiologic Locomotor activity Male Motor Activity Motor task performance Neostriatum Neurobiology Neurology Neurosciences Open Field Test Physical Conditioning, Animal Physical training Raclopride Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Running Teenagers Wheel running |
| title | Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors |
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