NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway

Aberrant Notch activation has been implicated in multiple malignancies and the identification of NOTCH receptors and related pathways is critical for targeted therapy. In this study, we aim to delineate the most prominent dysregulated NOTCH receptor and comprehensively reveal its deregulation in gas...

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Veröffentlicht in:	Oncogene 2021-03, Vol.40 (9), p.1578-1594
Hauptverfasser:	Kang, Wei, Zhang, Jinglin, Huang, Tingting, Zhou, Yuhang, Wong, Chi Chun, Chan, Ronald C. K., Dong, Yujuan, Wu, Feng, Zhang, Bin, Wu, William K. K., Chan, Michael W. Y., Cheng, Alfred S. L., Yu, Jun, Wong, Nathalie, Lo, Kwok Wai, To, Ka Fai
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/31 14/19 38/77 38/91 45 631/67/1504/1829 631/67/1857 64/60 82/80 AKT protein Antitumor activity Apoptosis Apoptosis - genetics Carcinogenesis Carcinogenesis - genetics Care and treatment Carrier Proteins - genetics Cell Biology Cell cycle Cell growth Cell Line, Tumor Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Cisplatin Cisplatin - pharmacology Datasets Development and progression Drug Resistance, Neoplasm - genetics Epigenetics Epstein-Barr virus Fluorouracil - pharmacology Gastric cancer Gene amplification Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genetic regulation Health aspects Human Genetics Humans Infections Internal Medicine Medicine Medicine & Public Health MicroRNA MicroRNAs MicroRNAs - genetics miRNA Molecular modelling Mutation Notch protein Notch3 protein Oncogene Protein v-akt - genetics Oncology Pathogenesis Receptor, Notch3 - genetics RNA, Small Interfering - genetics siRNA Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - pathology TOR protein TOR Serine-Threonine Kinases - genetics Tumor suppressor genes Tumors
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