Microbial Diversity and Composition Is Associated with Patient-Reported Toxicity during Chemoradiation Therapy for Cervical Cancer

Patients receiving pelvic radiation for cervical cancer experience high rates of acute gastrointestinal (GI) toxicity. The association of changes in the gut microbiome with bowel toxicity from radiation is not well characterized. Thirty-five patients undergoing definitive chemoradiation therapy (CRT...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2020-05, Vol.107 (1), p.163-171
Hauptverfasser:	Mitra, Aparna, Grossman Biegert, Greyson Willis, Delgado, Andrea Y., Karpinets, Tatiana V., Solley, Travis N., Mezzari, Melissa P., Yoshida-Court, Kyoko, Petrosino, Joe F., Mikkelson, Megan D., Lin, Lilie, Eifel, Patricia, Zhang, Jianhua, Ramondetta, Lois M., Jhingran, Anuja, Sims, Travis T., Schmeler, Kathleen, Okhuysen, Pablo, Colbert, Lauren E., Klopp, Ann H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biodiversity Chemoradiotherapy - adverse effects Cohort Studies Female Gastrointestinal Microbiome - radiation effects Gastrointestinal Tract - microbiology Gastrointestinal Tract - radiation effects Humans Middle Aged Patient Reported Outcome Measures Safety Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - microbiology Uterine Cervical Neoplasms - radiotherapy Uterine Cervical Neoplasms - therapy
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