Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV‑2 Spike Proteins by ACE2-Designed Peptides

Angiotensin-converting enzyme 2 (ACE2) is the host cellular receptor that locks onto the surface spike protein of the 2002 SARS coronavirus (SARS-CoV-1) and of the novel, highly transmissible and deadly 2019 SARS-CoV-2, responsible for the COVID-19 pandemic. One strategy to avoid the virus infection...

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Veröffentlicht in:	Journal of chemical information and modeling 2021-03, Vol.61 (3), p.1226-1243
Hauptverfasser:	Freitas, Frederico Campos, Ferreira, Paulo Henrique Borges, Favaro, Denize Cristina, Oliveira, Ronaldo Junio de
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Angiotensin-Converting Enzyme 2 - metabolism Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding Computational Chemistry Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - metabolism Domains Drug Design Folding Humans Models, Molecular Peptidases Peptides Peptides - chemistry Peptides - pharmacology Protein Binding - drug effects Protein Domains - drug effects Proteins SARS Virus - drug effects SARS Virus - metabolism SARS-CoV-2 - drug effects SARS-CoV-2 - metabolism Severe Acute Respiratory Syndrome - drug therapy Severe Acute Respiratory Syndrome - metabolism Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism Viral diseases Viruses
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