HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans
ObjectivesTo examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quanti...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2020-01, Vol.106 (2), p.147-153 |
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| creator | Buggey, Jonathan Yun, Leo Hung, Chung-Lieh Kityo, Cissy Mirembe, Grace Erem, Geoffrey Truong, Tiffany Ssinabulya, Isaac Tang, W H Wilson Hoit, Brian D McComsey, Grace A Longenecker, Chris T |
| description | ObjectivesTo examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quantity and radiodensity of fat surrounding the heart relates to cardiac dysfunction in this population is unknown.MethodsOne hundred HIV-positive Ugandans on antiretroviral therapy were compared with 100 age and sex-matched HIV-negative Ugandans; all were >45 years old with >1 cardiovascular disease risk factor. Subjects underwent ECG-gated non-contrast cardiac CT and transthoracic echocardiography with speckle tracking strain imaging. Multivariable linear and logistic regression models were used to explore the association of PCF with echocardiographic outcomes.ResultsMedian age was 55% and 62% were female. Compared with uninfected controls, PLHIV had lower body mass index (27 vs 30, p=0.02) and less diabetes (26% vs 45%, p=0.005). Median left ventricular (LV) ejection fraction was 67%. In models adjusted for traditional risk factors, HIV was associated with 10.3 g/m2 higher LV mass index (LVMI) (95% CI 3.22 to 17.4; p=0.005), 0.87% worse LV global longitudinal strain (GLS) (95% CI −1.66 to −0.07; p=0.03) and higher odds of diastolic dysfunction (OR 1.96; 95% CI 0.95 to 4.06; p=0.07). In adjusted models, PCF volume was significantly associated with increased LVMI and worse LV GLS, while PCF radiodensity was associated with worse LV GLS (all p |
| doi_str_mv | 10.1136/heartjnl-2019-315346 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7927634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2295463218</sourcerecordid><originalsourceid>FETCH-LOGICAL-b517t-a74f52517fc4c86a1aefb7464cd72f2f5afa56dc947b45cecb89229aab1ab2523</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxSMEoqXwDRCyxKWX0Njxn-SChKpCK1XiQhE3a-zYu14l9mI7oH77Okq7QA8VJ4_Gv_c841dVb3HzAeOWn20NxLzzY00a3NctZi3lz6pjTHm3tH48L3XLWM2bVhxVr1LaNU1D-46_rI4WWvBWHFfq8uo7Aj-gvYlOQxwcjMhCRhANgpSCdpDNgH67vEWgfIhTAVZQo5TjrPO8oMXCzl5nFzyCKfgNutmUJvj0unphYUzmzf15Ut18vvh2fllff_1ydf7pulYMi1yDoJaRUlpNdccBg7FKUE71IIglloEFxgfdU6Eo00arriekB1AYFGGkPak-rr77WU1m0MbnCKPcRzdBvJUBnPz3xrut3IRfUvSkfAYtBqf3BjH8nE3KcnJJm3EEb8KcZHmNUd4S3BX0_SN0F-boy3qStFQwRjrGC0VXSseQUjT2MAxu5BKifAhRLiHKNcQie_f3IgfRQ2oFOFsBNe3-17L5oziM-qTkDgyVu1Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2347552856</pqid></control><display><type>article</type><title>HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans</title><source>MEDLINE</source><source>PubMed Central</source><creator>Buggey, Jonathan ; Yun, Leo ; Hung, Chung-Lieh ; Kityo, Cissy ; Mirembe, Grace ; Erem, Geoffrey ; Truong, Tiffany ; Ssinabulya, Isaac ; Tang, W H Wilson ; Hoit, Brian D ; McComsey, Grace A ; Longenecker, Chris T</creator><creatorcontrib>Buggey, Jonathan ; Yun, Leo ; Hung, Chung-Lieh ; Kityo, Cissy ; Mirembe, Grace ; Erem, Geoffrey ; Truong, Tiffany ; Ssinabulya, Isaac ; Tang, W H Wilson ; Hoit, Brian D ; McComsey, Grace A ; Longenecker, Chris T</creatorcontrib><description>ObjectivesTo examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quantity and radiodensity of fat surrounding the heart relates to cardiac dysfunction in this population is unknown.MethodsOne hundred HIV-positive Ugandans on antiretroviral therapy were compared with 100 age and sex-matched HIV-negative Ugandans; all were >45 years old with >1 cardiovascular disease risk factor. Subjects underwent ECG-gated non-contrast cardiac CT and transthoracic echocardiography with speckle tracking strain imaging. Multivariable linear and logistic regression models were used to explore the association of PCF with echocardiographic outcomes.ResultsMedian age was 55% and 62% were female. Compared with uninfected controls, PLHIV had lower body mass index (27 vs 30, p=0.02) and less diabetes (26% vs 45%, p=0.005). Median left ventricular (LV) ejection fraction was 67%. In models adjusted for traditional risk factors, HIV was associated with 10.3 g/m2 higher LV mass index (LVMI) (95% CI 3.22 to 17.4; p=0.005), 0.87% worse LV global longitudinal strain (GLS) (95% CI −1.66 to −0.07; p=0.03) and higher odds of diastolic dysfunction (OR 1.96; 95% CI 0.95 to 4.06; p=0.07). In adjusted models, PCF volume was significantly associated with increased LVMI and worse LV GLS, while PCF radiodensity was associated with worse LV GLS (all p<0.05).ConclusionsIn Uganda, HIV infection, PCF volume and density are associated with abnormal cardiac structure and function.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2019-315346</identifier><identifier>PMID: 31537637</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Adipose Tissue - diagnostic imaging ; Adipose Tissue - physiopathology ; Adiposity ; Age ; Blood pressure ; Cardiovascular disease ; Case-Control Studies ; Coronary vessels ; Diabetes ; Ejection fraction ; Family medical history ; Female ; HIV ; HIV-Associated Lipodystrophy Syndrome - complications ; HIV-Associated Lipodystrophy Syndrome - diagnostic imaging ; HIV-Associated Lipodystrophy Syndrome - physiopathology ; Human immunodeficiency virus ; Humans ; Hypertension ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - physiopathology ; LV GLS ; Male ; Middle Aged ; pericardial fat ; Pericardium ; Population ; Prospective Studies ; Pulmonary arteries ; Risk Assessment ; Risk Factors ; Special populations ; Uganda ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left ; Ventricular Remodeling</subject><ispartof>Heart (British Cardiac Society), 2020-01, Vol.106 (2), p.147-153</ispartof><rights>Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b517t-a74f52517fc4c86a1aefb7464cd72f2f5afa56dc947b45cecb89229aab1ab2523</citedby><cites>FETCH-LOGICAL-b517t-a74f52517fc4c86a1aefb7464cd72f2f5afa56dc947b45cecb89229aab1ab2523</cites><orcidid>0000-0001-8450-7236</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927634/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927634/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31537637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buggey, Jonathan</creatorcontrib><creatorcontrib>Yun, Leo</creatorcontrib><creatorcontrib>Hung, Chung-Lieh</creatorcontrib><creatorcontrib>Kityo, Cissy</creatorcontrib><creatorcontrib>Mirembe, Grace</creatorcontrib><creatorcontrib>Erem, Geoffrey</creatorcontrib><creatorcontrib>Truong, Tiffany</creatorcontrib><creatorcontrib>Ssinabulya, Isaac</creatorcontrib><creatorcontrib>Tang, W H Wilson</creatorcontrib><creatorcontrib>Hoit, Brian D</creatorcontrib><creatorcontrib>McComsey, Grace A</creatorcontrib><creatorcontrib>Longenecker, Chris T</creatorcontrib><title>HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>ObjectivesTo examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quantity and radiodensity of fat surrounding the heart relates to cardiac dysfunction in this population is unknown.MethodsOne hundred HIV-positive Ugandans on antiretroviral therapy were compared with 100 age and sex-matched HIV-negative Ugandans; all were >45 years old with >1 cardiovascular disease risk factor. Subjects underwent ECG-gated non-contrast cardiac CT and transthoracic echocardiography with speckle tracking strain imaging. Multivariable linear and logistic regression models were used to explore the association of PCF with echocardiographic outcomes.ResultsMedian age was 55% and 62% were female. Compared with uninfected controls, PLHIV had lower body mass index (27 vs 30, p=0.02) and less diabetes (26% vs 45%, p=0.005). Median left ventricular (LV) ejection fraction was 67%. In models adjusted for traditional risk factors, HIV was associated with 10.3 g/m2 higher LV mass index (LVMI) (95% CI 3.22 to 17.4; p=0.005), 0.87% worse LV global longitudinal strain (GLS) (95% CI −1.66 to −0.07; p=0.03) and higher odds of diastolic dysfunction (OR 1.96; 95% CI 0.95 to 4.06; p=0.07). In adjusted models, PCF volume was significantly associated with increased LVMI and worse LV GLS, while PCF radiodensity was associated with worse LV GLS (all p<0.05).ConclusionsIn Uganda, HIV infection, PCF volume and density are associated with abnormal cardiac structure and function.</description><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - physiopathology</subject><subject>Adiposity</subject><subject>Age</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Ejection fraction</subject><subject>Family medical history</subject><subject>Female</subject><subject>HIV</subject><subject>HIV-Associated Lipodystrophy Syndrome - complications</subject><subject>HIV-Associated Lipodystrophy Syndrome - diagnostic imaging</subject><subject>HIV-Associated Lipodystrophy Syndrome - physiopathology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>LV GLS</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pericardial fat</subject><subject>Pericardium</subject><subject>Population</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Special populations</subject><subject>Uganda</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Remodeling</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9v1DAQxSMEoqXwDRCyxKWX0Njxn-SChKpCK1XiQhE3a-zYu14l9mI7oH77Okq7QA8VJ4_Gv_c841dVb3HzAeOWn20NxLzzY00a3NctZi3lz6pjTHm3tH48L3XLWM2bVhxVr1LaNU1D-46_rI4WWvBWHFfq8uo7Aj-gvYlOQxwcjMhCRhANgpSCdpDNgH67vEWgfIhTAVZQo5TjrPO8oMXCzl5nFzyCKfgNutmUJvj0unphYUzmzf15Ut18vvh2fllff_1ydf7pulYMi1yDoJaRUlpNdccBg7FKUE71IIglloEFxgfdU6Eo00arriekB1AYFGGkPak-rr77WU1m0MbnCKPcRzdBvJUBnPz3xrut3IRfUvSkfAYtBqf3BjH8nE3KcnJJm3EEb8KcZHmNUd4S3BX0_SN0F-boy3qStFQwRjrGC0VXSseQUjT2MAxu5BKifAhRLiHKNcQie_f3IgfRQ2oFOFsBNe3-17L5oziM-qTkDgyVu1Y</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Buggey, Jonathan</creator><creator>Yun, Leo</creator><creator>Hung, Chung-Lieh</creator><creator>Kityo, Cissy</creator><creator>Mirembe, Grace</creator><creator>Erem, Geoffrey</creator><creator>Truong, Tiffany</creator><creator>Ssinabulya, Isaac</creator><creator>Tang, W H Wilson</creator><creator>Hoit, Brian D</creator><creator>McComsey, Grace A</creator><creator>Longenecker, Chris T</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8450-7236</orcidid></search><sort><creationdate>20200101</creationdate><title>HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans</title><author>Buggey, Jonathan ; Yun, Leo ; Hung, Chung-Lieh ; Kityo, Cissy ; Mirembe, Grace ; Erem, Geoffrey ; Truong, Tiffany ; Ssinabulya, Isaac ; Tang, W H Wilson ; Hoit, Brian D ; McComsey, Grace A ; Longenecker, Chris T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b517t-a74f52517fc4c86a1aefb7464cd72f2f5afa56dc947b45cecb89229aab1ab2523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - physiopathology</topic><topic>Adiposity</topic><topic>Age</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Ejection fraction</topic><topic>Family medical history</topic><topic>Female</topic><topic>HIV</topic><topic>HIV-Associated Lipodystrophy Syndrome - complications</topic><topic>HIV-Associated Lipodystrophy Syndrome - diagnostic imaging</topic><topic>HIV-Associated Lipodystrophy Syndrome - physiopathology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>LV GLS</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pericardial fat</topic><topic>Pericardium</topic><topic>Population</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Special populations</topic><topic>Uganda</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buggey, Jonathan</creatorcontrib><creatorcontrib>Yun, Leo</creatorcontrib><creatorcontrib>Hung, Chung-Lieh</creatorcontrib><creatorcontrib>Kityo, Cissy</creatorcontrib><creatorcontrib>Mirembe, Grace</creatorcontrib><creatorcontrib>Erem, Geoffrey</creatorcontrib><creatorcontrib>Truong, Tiffany</creatorcontrib><creatorcontrib>Ssinabulya, Isaac</creatorcontrib><creatorcontrib>Tang, W H Wilson</creatorcontrib><creatorcontrib>Hoit, Brian D</creatorcontrib><creatorcontrib>McComsey, Grace A</creatorcontrib><creatorcontrib>Longenecker, Chris T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buggey, Jonathan</au><au>Yun, Leo</au><au>Hung, Chung-Lieh</au><au>Kityo, Cissy</au><au>Mirembe, Grace</au><au>Erem, Geoffrey</au><au>Truong, Tiffany</au><au>Ssinabulya, Isaac</au><au>Tang, W H Wilson</au><au>Hoit, Brian D</au><au>McComsey, Grace A</au><au>Longenecker, Chris T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>106</volume><issue>2</issue><spage>147</spage><epage>153</epage><pages>147-153</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>ObjectivesTo examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quantity and radiodensity of fat surrounding the heart relates to cardiac dysfunction in this population is unknown.MethodsOne hundred HIV-positive Ugandans on antiretroviral therapy were compared with 100 age and sex-matched HIV-negative Ugandans; all were >45 years old with >1 cardiovascular disease risk factor. Subjects underwent ECG-gated non-contrast cardiac CT and transthoracic echocardiography with speckle tracking strain imaging. Multivariable linear and logistic regression models were used to explore the association of PCF with echocardiographic outcomes.ResultsMedian age was 55% and 62% were female. Compared with uninfected controls, PLHIV had lower body mass index (27 vs 30, p=0.02) and less diabetes (26% vs 45%, p=0.005). Median left ventricular (LV) ejection fraction was 67%. In models adjusted for traditional risk factors, HIV was associated with 10.3 g/m2 higher LV mass index (LVMI) (95% CI 3.22 to 17.4; p=0.005), 0.87% worse LV global longitudinal strain (GLS) (95% CI −1.66 to −0.07; p=0.03) and higher odds of diastolic dysfunction (OR 1.96; 95% CI 0.95 to 4.06; p=0.07). In adjusted models, PCF volume was significantly associated with increased LVMI and worse LV GLS, while PCF radiodensity was associated with worse LV GLS (all p<0.05).ConclusionsIn Uganda, HIV infection, PCF volume and density are associated with abnormal cardiac structure and function.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>31537637</pmid><doi>10.1136/heartjnl-2019-315346</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8450-7236</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - diagnostic imaging Adipose Tissue - physiopathology Adiposity Age Blood pressure Cardiovascular disease Case-Control Studies Coronary vessels Diabetes Ejection fraction Family medical history Female HIV HIV-Associated Lipodystrophy Syndrome - complications HIV-Associated Lipodystrophy Syndrome - diagnostic imaging HIV-Associated Lipodystrophy Syndrome - physiopathology Human immunodeficiency virus Humans Hypertension Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - physiopathology LV GLS Male Middle Aged pericardial fat Pericardium Population Prospective Studies Pulmonary arteries Risk Assessment Risk Factors Special populations Uganda Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Remodeling |
| title | HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans |
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