Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates

Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-12, Vol.33 (13), p.108562-108562, Article 108562
Hauptverfasser:	Patananan, Alexander N., Sercel, Alexander J., Wu, Ting-Hsiang, Ahsan, Fasih M., Torres, Alejandro, Kennedy, Stephanie A.L., Vandiver, Amy, Collier, Amanda J., Mehrabi, Artin, Van Lew, Jon, Zakin, Lise, Rodriguez, Noe, Sixto, Marcos, Tadros, Wael, Lazar, Adam, Sieling, Peter A., Nguyen, Thang L., Dawson, Emma R., Braas, Daniel, Golovato, Justin, Cisneros, Luis, Vaske, Charles, Plath, Kathrin, Rabizadeh, Shahrooz, Niazi, Kayvan R., Chiou, Pei-Yu, Teitell, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	cell engineering differentiation, MitoPunch, mitochondrial transplantation, mitochondrial replacement, mitonuclear communication, isolated mitochondria mitochondrial transfer mtDNA reprogramming
Online-Zugang:	Volltext
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