Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy

Cancer therapies kill tumors either directly or indirectly by evoking immune responses and have been combined with varying levels of success. Here, we describe a paradigm to control cancer growth that is based on both direct tumor killing and the triggering of protective immunity. Genetic ablation o...

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Veröffentlicht in:	Cell 2020-11, Vol.183 (5), p.1219-1233.e18
Hauptverfasser:	Jiang, Liwei, Wang, Yi-Jun, Zhao, Jing, Uehara, Mayuko, Hou, Qingming, Kasinath, Vivek, Ichimura, Takaharu, Banouni, Naima, Dai, Li, Li, Xiaofei, Greiner, Dale L., Shultz, Leonard D., Zhang, Xiaolong, Sun, Zhen-Yu Jim, Curtin, Ian, Vangos, Nicholas E., Yeoh, Zoe C., Geffken, Ezekiel A., Seo, Hyuk-Soo, Liu, Ze-Xian, Heffron, Gregory J., Shah, Khalid, Dhe-Paganon, Sirano, Abdi, Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor immune response cancer-associated fibroblasts granzyme B SerpinB9
Online-Zugang:	Volltext
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