Quantification of Bacteria in Mouth-Rinsing Solution for the Diagnosis of Periodontal Disease
This study aimed to evaluate the feasibility of diagnosing periodontitis via the identification of 18 bacterial species in mouth-rinse samples. Patients (n = 110) who underwent dental examinations in the Department of Periodontology at the Veterans Health Service Medical Center between 2018 and 2019...
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| Veröffentlicht in: | Journal of clinical medicine 2021-02, Vol.10 (4), p.891 |
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| creator | Kim, Jeong-Hwa Oh, Jae-Woon Lee, Young Yun, Jeong-Ho Choi, Seong-Ho Lee, Dong-Woon |
| description | This study aimed to evaluate the feasibility of diagnosing periodontitis via the identification of 18 bacterial species in mouth-rinse samples. Patients (n = 110) who underwent dental examinations in the Department of Periodontology at the Veterans Health Service Medical Center between 2018 and 2019 were included. They were divided into healthy and periodontitis groups. The overall number of bacteria, and those of 18 specific bacteria, were determined via real-time polymerase chain reaction in 92 mouth-rinse samples. Differences between groups were evaluated through logistic regression after adjusting for sex, age, and smoking history. There was a significant difference in the prevalence (healthy vs. periodontitis group) of
(2.9% vs. 13.5%),
(42.9% vs. 69.2%), and
(80% vs. 2.7%). Levels of
,
, and
were significantly associated with severe periodontitis. We demonstrated the feasibility of detecting periopathogenic bacteria in mouth-rinse samples obtained from patients with periodontitis. As we did not comprehensively assess all periopathogenic bacteria, further studies are required to assess the potential of oral-rinsing solutions to indicate oral infection risk and the need to improve oral hygiene, and to serve as a complementary method for periodontal disease diagnosis. |
| doi_str_mv | 10.3390/jcm10040891 |
| format | Article |
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(2.9% vs. 13.5%),
(42.9% vs. 69.2%), and
(80% vs. 2.7%). Levels of
,
, and
were significantly associated with severe periodontitis. We demonstrated the feasibility of detecting periopathogenic bacteria in mouth-rinse samples obtained from patients with periodontitis. As we did not comprehensively assess all periopathogenic bacteria, further studies are required to assess the potential of oral-rinsing solutions to indicate oral infection risk and the need to improve oral hygiene, and to serve as a complementary method for periodontal disease diagnosis.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10040891</identifier><identifier>PMID: 33671765</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bacteria ; Clinical medicine ; Deoxyribonucleic acid ; DNA ; Gum disease ; Health services ; Mouth ; Patients ; Periodontics ; Plasmids ; Sample size</subject><ispartof>Journal of clinical medicine, 2021-02, Vol.10 (4), p.891</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-325c64e9ec4ddeaf7d5a9f8136464dd400fc033f6319a18997f8566243ce26353</citedby><cites>FETCH-LOGICAL-c409t-325c64e9ec4ddeaf7d5a9f8136464dd400fc033f6319a18997f8566243ce26353</cites><orcidid>0000-0001-6704-6124 ; 0000-0003-3929-4467 ; 0000-0002-0796-9100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926621/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926621/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33671765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jeong-Hwa</creatorcontrib><creatorcontrib>Oh, Jae-Woon</creatorcontrib><creatorcontrib>Lee, Young</creatorcontrib><creatorcontrib>Yun, Jeong-Ho</creatorcontrib><creatorcontrib>Choi, Seong-Ho</creatorcontrib><creatorcontrib>Lee, Dong-Woon</creatorcontrib><title>Quantification of Bacteria in Mouth-Rinsing Solution for the Diagnosis of Periodontal Disease</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>This study aimed to evaluate the feasibility of diagnosing periodontitis via the identification of 18 bacterial species in mouth-rinse samples. Patients (n = 110) who underwent dental examinations in the Department of Periodontology at the Veterans Health Service Medical Center between 2018 and 2019 were included. They were divided into healthy and periodontitis groups. The overall number of bacteria, and those of 18 specific bacteria, were determined via real-time polymerase chain reaction in 92 mouth-rinse samples. Differences between groups were evaluated through logistic regression after adjusting for sex, age, and smoking history. There was a significant difference in the prevalence (healthy vs. periodontitis group) of
(2.9% vs. 13.5%),
(42.9% vs. 69.2%), and
(80% vs. 2.7%). Levels of
,
, and
were significantly associated with severe periodontitis. We demonstrated the feasibility of detecting periopathogenic bacteria in mouth-rinse samples obtained from patients with periodontitis. As we did not comprehensively assess all periopathogenic bacteria, further studies are required to assess the potential of oral-rinsing solutions to indicate oral infection risk and the need to improve oral hygiene, and to serve as a complementary method for periodontal disease diagnosis.</description><subject>Bacteria</subject><subject>Clinical medicine</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gum disease</subject><subject>Health services</subject><subject>Mouth</subject><subject>Patients</subject><subject>Periodontics</subject><subject>Plasmids</subject><subject>Sample size</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkd1LBCEUxSWKNqqn3mOglyCmdHQcfQn6Lij6fgwxR3ddZrXUCfrvs3ZbtnxR7v3dw7keALYQ3MeYw4OxmiAICWQcLYG1CjZNCTHDywvvAdiMcQzzYYxUqFkFA4xpgxpar4GX-166ZI1VMlnvCm-KY6mSDlYW1hU3vk-j8sG6aN2wePRd_0MZH4o00sWplUPno43fc3d5yLfeJdnlRtQy6g2wYmQX9ebsXgfP52dPJ5fl9e3F1cnRdakI5KnEVa0o0Vwr0rZamqatJTcMYUporhAIjYIYG4oRl4hx3hhWU1oRrHRFcY3XweFU961_nehWaZeC7MRbsBMZPoWXVvztODsSQ_8hGl5lHZQFdmcCwb_3OiYxsVHprpNO-z6KinBGMgtpRnf-oWPfB5fXExUlKP84QzxTe1NKBR9j0GZuBkHxnZxYSC7T24v-5-xvTvgLKbST8Q</recordid><startdate>20210222</startdate><enddate>20210222</enddate><creator>Kim, Jeong-Hwa</creator><creator>Oh, Jae-Woon</creator><creator>Lee, Young</creator><creator>Yun, Jeong-Ho</creator><creator>Choi, Seong-Ho</creator><creator>Lee, Dong-Woon</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6704-6124</orcidid><orcidid>https://orcid.org/0000-0003-3929-4467</orcidid><orcidid>https://orcid.org/0000-0002-0796-9100</orcidid></search><sort><creationdate>20210222</creationdate><title>Quantification of Bacteria in Mouth-Rinsing Solution for the Diagnosis of Periodontal Disease</title><author>Kim, Jeong-Hwa ; Oh, Jae-Woon ; Lee, Young ; Yun, Jeong-Ho ; Choi, Seong-Ho ; Lee, Dong-Woon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-325c64e9ec4ddeaf7d5a9f8136464dd400fc033f6319a18997f8566243ce26353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bacteria</topic><topic>Clinical medicine</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Gum disease</topic><topic>Health services</topic><topic>Mouth</topic><topic>Patients</topic><topic>Periodontics</topic><topic>Plasmids</topic><topic>Sample size</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jeong-Hwa</creatorcontrib><creatorcontrib>Oh, Jae-Woon</creatorcontrib><creatorcontrib>Lee, Young</creatorcontrib><creatorcontrib>Yun, Jeong-Ho</creatorcontrib><creatorcontrib>Choi, Seong-Ho</creatorcontrib><creatorcontrib>Lee, Dong-Woon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jeong-Hwa</au><au>Oh, Jae-Woon</au><au>Lee, Young</au><au>Yun, Jeong-Ho</au><au>Choi, Seong-Ho</au><au>Lee, Dong-Woon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of Bacteria in Mouth-Rinsing Solution for the Diagnosis of Periodontal Disease</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2021-02-22</date><risdate>2021</risdate><volume>10</volume><issue>4</issue><spage>891</spage><pages>891-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>This study aimed to evaluate the feasibility of diagnosing periodontitis via the identification of 18 bacterial species in mouth-rinse samples. Patients (n = 110) who underwent dental examinations in the Department of Periodontology at the Veterans Health Service Medical Center between 2018 and 2019 were included. They were divided into healthy and periodontitis groups. The overall number of bacteria, and those of 18 specific bacteria, were determined via real-time polymerase chain reaction in 92 mouth-rinse samples. Differences between groups were evaluated through logistic regression after adjusting for sex, age, and smoking history. There was a significant difference in the prevalence (healthy vs. periodontitis group) of
(2.9% vs. 13.5%),
(42.9% vs. 69.2%), and
(80% vs. 2.7%). Levels of
,
, and
were significantly associated with severe periodontitis. We demonstrated the feasibility of detecting periopathogenic bacteria in mouth-rinse samples obtained from patients with periodontitis. As we did not comprehensively assess all periopathogenic bacteria, further studies are required to assess the potential of oral-rinsing solutions to indicate oral infection risk and the need to improve oral hygiene, and to serve as a complementary method for periodontal disease diagnosis.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33671765</pmid><doi>10.3390/jcm10040891</doi><orcidid>https://orcid.org/0000-0001-6704-6124</orcidid><orcidid>https://orcid.org/0000-0003-3929-4467</orcidid><orcidid>https://orcid.org/0000-0002-0796-9100</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bacteria Clinical medicine Deoxyribonucleic acid DNA Gum disease Health services Mouth Patients Periodontics Plasmids Sample size |
| title | Quantification of Bacteria in Mouth-Rinsing Solution for the Diagnosis of Periodontal Disease |
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