Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration

[Display omitted] Aggregates or oligomeric forms of many intrinsically disordered proteins (IDPs), including α-synuclein, are hallmarks of neurodegenerative diseases, like Parkinson’s and Alzheimer’s disease, and key contributors to their pathogenesis. Due to their disordered nature and therefore la...

Ausführliche Beschreibung