Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
We herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimm...
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| Veröffentlicht in: | Internal Medicine 2021/02/01, Vol.60(3), pp.409-415 |
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| creator | Ohtsubo, Koushiro Yamashita, Kaname Yanagimura, Naohiro Suzuki, Chiaki Tanimoto, Azusa Nishiyama, Akihiro Takeuchi, Shinji Iwaki, Noriko Kawano, Mitsuhiro Izumozaki, Akira Inoue, Dai Gabata, Toshifumi Ikeda, Hiroko Watanabe, Michio Yano, Seiji |
| description | We herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimmune pancreatitis. Her serum IgG4 concentration was elevated to 674 mg/dL. After the pancreatic head mass spontaneously diminished, three masses were detected in the common bile duct. A biopsy of the major papilla revealed high-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangement. Systemic chemotherapy with rituximab plus etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin resulted in complete remission. |
| doi_str_mv | 10.2169/internalmedicine.5429-20 |
| format | Article |
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Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimmune pancreatitis. Her serum IgG4 concentration was elevated to 674 mg/dL. After the pancreatic head mass spontaneously diminished, three masses were detected in the common bile duct. A biopsy of the major papilla revealed high-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangement. Systemic chemotherapy with rituximab plus etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin resulted in complete remission.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.5429-20</identifier><identifier>PMID: 32863365</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Autoimmune Pancreatitis ; automiine pancreatitis ; B-cell lymphoma ; Bcl-6 protein ; Beta cells ; Bile ; bile duct ; Bile Ducts ; Biopsy ; Case Report ; Chemotherapy ; Computed tomography ; Cyclophosphamide ; Doxorubicin ; Etoposide ; Female ; high-grade B-cell lymphoma ; Humans ; IgG4-related disease ; Immunoglobulin G ; Internal medicine ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse - drug therapy ; Monoclonal antibodies ; Myc protein ; non-Hodgkin lymphoma ; Pancreas ; Pancreatic cancer ; Pancreatitis ; Prednisolone ; Prednisone - therapeutic use ; Proto-Oncogene Proteins c-bcl-2 - therapeutic use ; Proto-Oncogene Proteins c-bcl-6 ; Remission ; Rituximab ; Targeted cancer therapy ; Vincristine ; with MYC and BCL2 and/or BCL6 rearrangements</subject><ispartof>Internal Medicine, 2021/02/01, Vol.60(3), pp.409-415</ispartof><rights>2021 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><rights>Copyright © 2021 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c666t-259afa0269be1c0078c4c1f6298a67b1022bc1d6fff7eb26962e97d4b23a133b3</citedby><cites>FETCH-LOGICAL-c666t-259afa0269be1c0078c4c1f6298a67b1022bc1d6fff7eb26962e97d4b23a133b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925286/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925286/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,1879,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32863365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohtsubo, Koushiro</creatorcontrib><creatorcontrib>Yamashita, Kaname</creatorcontrib><creatorcontrib>Yanagimura, Naohiro</creatorcontrib><creatorcontrib>Suzuki, Chiaki</creatorcontrib><creatorcontrib>Tanimoto, Azusa</creatorcontrib><creatorcontrib>Nishiyama, Akihiro</creatorcontrib><creatorcontrib>Takeuchi, Shinji</creatorcontrib><creatorcontrib>Iwaki, Noriko</creatorcontrib><creatorcontrib>Kawano, Mitsuhiro</creatorcontrib><creatorcontrib>Izumozaki, Akira</creatorcontrib><creatorcontrib>Inoue, Dai</creatorcontrib><creatorcontrib>Gabata, Toshifumi</creatorcontrib><creatorcontrib>Ikeda, Hiroko</creatorcontrib><creatorcontrib>Watanabe, Michio</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><title>Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimmune pancreatitis. Her serum IgG4 concentration was elevated to 674 mg/dL. After the pancreatic head mass spontaneously diminished, three masses were detected in the common bile duct. A biopsy of the major papilla revealed high-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangement. Systemic chemotherapy with rituximab plus etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin resulted in complete remission.</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Autoimmune Pancreatitis</subject><subject>automiine pancreatitis</subject><subject>B-cell lymphoma</subject><subject>Bcl-6 protein</subject><subject>Beta cells</subject><subject>Bile</subject><subject>bile duct</subject><subject>Bile Ducts</subject><subject>Biopsy</subject><subject>Case Report</subject><subject>Chemotherapy</subject><subject>Computed tomography</subject><subject>Cyclophosphamide</subject><subject>Doxorubicin</subject><subject>Etoposide</subject><subject>Female</subject><subject>high-grade B-cell lymphoma</subject><subject>Humans</subject><subject>IgG4-related disease</subject><subject>Immunoglobulin G</subject><subject>Internal medicine</subject><subject>Lymphoma</subject><subject>Lymphoma, Large B-Cell, Diffuse - drug therapy</subject><subject>Monoclonal antibodies</subject><subject>Myc protein</subject><subject>non-Hodgkin lymphoma</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatitis</subject><subject>Prednisolone</subject><subject>Prednisone - therapeutic use</subject><subject>Proto-Oncogene Proteins c-bcl-2 - therapeutic use</subject><subject>Proto-Oncogene Proteins c-bcl-6</subject><subject>Remission</subject><subject>Rituximab</subject><subject>Targeted cancer therapy</subject><subject>Vincristine</subject><subject>with MYC and BCL2 and/or BCL6 rearrangements</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkctu1DAUhi0EosPAKyBLbNik-JI48QaptNykKSAua8vxnGQ8OHZqO5W64N1JNMMIyuacxfnO7f8RwpScMyrkK-szRK_dAFtrrIfzqmSyYOQBWlFeyqJmvHqIVkTSpmBzOENPUtoTwptassfojLNGcC6qFfp1PblsRwf4Wjvbe-0z3twN4y4MOuHQ4bwD_MbO9avJZHwFt-DCaH2PdTffgL-NwWftIUwJf4U-Qko2-KVRe3wx5WCHYfKAv2hvIuhss02Fsz-XfSk9RY867RI8O-Y1-vHu7ffLD8Xm8_uPlxebwgghcsEqqTtNmJAtUENI3ZjS0E4w2WhRt5Qw1hq6FV3X1dDOmGAg623ZMq4p5y1fo9eHuePUzpoZ8Dlqp8ZoBx3vVNBW_Vvxdqf6cKtmuapFqzV6eRwQw80EKavBJgPOHV5XrOSNlJzxBX1xD92HaTFroRpBG8JoM1PNgTIxpBShOx1DiVo8Vvc9VovHipG59fnfz5wa_5g6A58OwD5l3cMJ0DFb4-D_yYIovoTjhhNodjoq8Pw3rcXH-Q</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Ohtsubo, Koushiro</creator><creator>Yamashita, Kaname</creator><creator>Yanagimura, Naohiro</creator><creator>Suzuki, Chiaki</creator><creator>Tanimoto, Azusa</creator><creator>Nishiyama, Akihiro</creator><creator>Takeuchi, Shinji</creator><creator>Iwaki, Noriko</creator><creator>Kawano, Mitsuhiro</creator><creator>Izumozaki, Akira</creator><creator>Inoue, Dai</creator><creator>Gabata, Toshifumi</creator><creator>Ikeda, Hiroko</creator><creator>Watanabe, Michio</creator><creator>Yano, Seiji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210201</creationdate><title>Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass</title><author>Ohtsubo, Koushiro ; Yamashita, Kaname ; Yanagimura, Naohiro ; Suzuki, Chiaki ; Tanimoto, Azusa ; Nishiyama, Akihiro ; Takeuchi, Shinji ; Iwaki, Noriko ; Kawano, Mitsuhiro ; Izumozaki, Akira ; Inoue, Dai ; Gabata, Toshifumi ; Ikeda, Hiroko ; Watanabe, Michio ; Yano, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c666t-259afa0269be1c0078c4c1f6298a67b1022bc1d6fff7eb26962e97d4b23a133b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Autoimmune Pancreatitis</topic><topic>automiine pancreatitis</topic><topic>B-cell lymphoma</topic><topic>Bcl-6 protein</topic><topic>Beta cells</topic><topic>Bile</topic><topic>bile duct</topic><topic>Bile Ducts</topic><topic>Biopsy</topic><topic>Case Report</topic><topic>Chemotherapy</topic><topic>Computed tomography</topic><topic>Cyclophosphamide</topic><topic>Doxorubicin</topic><topic>Etoposide</topic><topic>Female</topic><topic>high-grade B-cell lymphoma</topic><topic>Humans</topic><topic>IgG4-related disease</topic><topic>Immunoglobulin G</topic><topic>Internal medicine</topic><topic>Lymphoma</topic><topic>Lymphoma, Large B-Cell, Diffuse - drug therapy</topic><topic>Monoclonal antibodies</topic><topic>Myc protein</topic><topic>non-Hodgkin lymphoma</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatitis</topic><topic>Prednisolone</topic><topic>Prednisone - therapeutic use</topic><topic>Proto-Oncogene Proteins c-bcl-2 - therapeutic use</topic><topic>Proto-Oncogene Proteins c-bcl-6</topic><topic>Remission</topic><topic>Rituximab</topic><topic>Targeted cancer therapy</topic><topic>Vincristine</topic><topic>with MYC and BCL2 and/or BCL6 rearrangements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohtsubo, Koushiro</creatorcontrib><creatorcontrib>Yamashita, Kaname</creatorcontrib><creatorcontrib>Yanagimura, Naohiro</creatorcontrib><creatorcontrib>Suzuki, Chiaki</creatorcontrib><creatorcontrib>Tanimoto, Azusa</creatorcontrib><creatorcontrib>Nishiyama, Akihiro</creatorcontrib><creatorcontrib>Takeuchi, Shinji</creatorcontrib><creatorcontrib>Iwaki, Noriko</creatorcontrib><creatorcontrib>Kawano, Mitsuhiro</creatorcontrib><creatorcontrib>Izumozaki, Akira</creatorcontrib><creatorcontrib>Inoue, Dai</creatorcontrib><creatorcontrib>Gabata, Toshifumi</creatorcontrib><creatorcontrib>Ikeda, Hiroko</creatorcontrib><creatorcontrib>Watanabe, Michio</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohtsubo, Koushiro</au><au>Yamashita, Kaname</au><au>Yanagimura, Naohiro</au><au>Suzuki, Chiaki</au><au>Tanimoto, Azusa</au><au>Nishiyama, Akihiro</au><au>Takeuchi, Shinji</au><au>Iwaki, Noriko</au><au>Kawano, Mitsuhiro</au><au>Izumozaki, Akira</au><au>Inoue, Dai</au><au>Gabata, Toshifumi</au><au>Ikeda, Hiroko</au><au>Watanabe, Michio</au><au>Yano, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| subjects | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autoimmune Pancreatitis automiine pancreatitis B-cell lymphoma Bcl-6 protein Beta cells Bile bile duct Bile Ducts Biopsy Case Report Chemotherapy Computed tomography Cyclophosphamide Doxorubicin Etoposide Female high-grade B-cell lymphoma Humans IgG4-related disease Immunoglobulin G Internal medicine Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Monoclonal antibodies Myc protein non-Hodgkin lymphoma Pancreas Pancreatic cancer Pancreatitis Prednisolone Prednisone - therapeutic use Proto-Oncogene Proteins c-bcl-2 - therapeutic use Proto-Oncogene Proteins c-bcl-6 Remission Rituximab Targeted cancer therapy Vincristine with MYC and BCL2 and/or BCL6 rearrangements |
| title | Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass |
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