De Novo Cholesterol Biosynthesis and Its Trafficking in LAMP-1-Positive Vesicles Are Involved in Replication and Spread of Marek's Disease Virus

Marek's disease virus (MDV) transforms CD4 T cells and causes a deadly neoplastic disease that is associated with metabolic dysregulation leading to atherosclerosis in chickens. While MDV-infected chickens have normal serum concentrations of cholesterol, their aortic tissues were found to have...

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Veröffentlicht in:	Journal of virology 2020-11, Vol.94 (24)
Hauptverfasser:	Boodhoo, Nitish, Kamble, Nitin, Behboudi, Shahriar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Viral Chickens - virology Cholesterol - biosynthesis Herpesvirus 2, Gallid - genetics Herpesvirus 2, Gallid - physiology Homeostasis Lanosterol - biosynthesis Lipid Metabolism Lipogenesis Lysosomal Membrane Proteins - genetics Lysosomal Membrane Proteins - metabolism Marek Disease - virology Mevalonic Acid - metabolism Protein Transport - physiology Transcription Factors - metabolism Viral Envelope Proteins Viral Proteins - metabolism Virus Replication - physiology Virus-Cell Interactions
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