A Structure-Function-Inhibition Analysis of the Pseudomonas aeruginosa Type III Secretion Needle Protein PscF

The type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in the gene provide resistance to the phenoxyacetamide (PhA) series of T3SS...

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Veröffentlicht in:	Journal of bacteriology 2020-08, Vol.202 (18)
Hauptverfasser:	Moir, Donald T, Bowlin, Nicholas O, Berube, Bryan J, Yabut, Jaden, Mills, Debra M, Nguyen, Giang T, Aron, Zachary D, Williams, John D, Mecsas, Joan, Hauser, Alan R, Bowlin, Terry L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - genetics Bacteriology Codons Cross-resistance Drug Resistance, Microbial - genetics Effector cells Inhibitors Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Loci Mutation Needles Phenotypes Phenoxyacetates - pharmacology Protein structure Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Resistant mutant Secretion Structure-Activity Relationship Structure-function relationships Toxins Translocation Type III Secretion Systems - antagonists & inhibitors
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