Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311

[Display omitted] Three antifungal macrolides cyphomycin (1), caniferolide C (2) and GT-35 (3) were isolated from Streptomyces sp. ISID311, a bacterial symbiont associated with Cyphomyrmex fungus-growing ants. The planar structures of these compounds were established by 1 and 2D NMR data and MS anal...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2021-02, Vol.32, p.116016-116016, Article 116016
Hauptverfasser:	Ortega, Humberto E., Lourenzon, Vitor B., Chevrette, Marc G., Ferreira, Leonardo L.G., Alvarenga, René F. Ramos, Melo, Weilan G.P., Venâncio, Tiago, Currie, Cameron R., Andricopulo, Adriano D., Bugni, Tim S., Pupo, Mônica T.
Format:	Artikel
Sprache:	eng
Schlagworte:	amastigotes antagonism Antiprotozoal Agents - chemistry Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology antiprotozoal properties bioinformatics biosynthesis Cyphomyrmex Dose-Response Relationship, Drug Fungus-growing ants humans inhibitory concentration 50 Leishmania donovani Leishmania donovani - drug effects Macrolides Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Molecular Structure multigene family parasites Parasitic Sensitivity Tests pathogens Polyketides stereochemistry Streptomyces Streptomyces - chemistry Structure-Activity Relationship symbionts
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