Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Analogous to the border customs, liver mainly functions as a filter to detoxify chemicals and metabolite administered orally or intravenously. Besides, the liver cancer cells overexpress the drug exporters w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of controlled release 2021-02, Vol.330, p.173-184
Hauptverfasser:	Wang, Hongzhi, Ellipilli, Satheesh, Lee, Wen-Jui, Li, Xin, Vieweger, Mario, Ho, Yuan-Soon, Guo, Peixuan
Format:	Artikel
Sprache:	eng
Schlagworte:	6-way junction Animals Carcinoma, Hepatocellular - drug therapy Cell Line, Tumor Drug Delivery Systems Drug Resistance, Neoplasm Hepatocyte targeting ligands Liver cancer therapy Liver Neoplasms - drug therapy Liver Neoplasms - genetics Mice MicroRNAs - genetics MicroRNAs - therapeutic use Nanoparticles Paclitaxel - therapeutic use Paclitaxel, MiRNA 122 Pharmaceutical Preparations RNA nanotechnology Rubber - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!