Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly
Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-...
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| Veröffentlicht in: | Nutrients 2021-02, Vol.13 (2), p.665 |
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| creator | Estébanez, Brisamar Visavadiya, Nishant P de Paz, José A Whitehurst, Michael Cuevas, María J González-Gallego, Javier Huang, Chun-Jung |
| description | Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA. |
| doi_str_mv | 10.3390/nu13020665 |
| format | Article |
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Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13020665</identifier><identifier>PMID: 33669497</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptation ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; CD14 antigen ; CD63 antigen ; CD81 antigen ; CD9 antigen ; Cell Communication ; Cell signaling ; Cell-Free Nucleic Acids - blood ; Deoxyribonucleic acid ; Diabetes ; DNA ; Ethylenediaminetetraacetic acid ; Exercise ; Exercise - physiology ; Exosomes - chemistry ; Exosomes - physiology ; Female ; Fitness training programs ; Gene Expression - physiology ; Geriatrics ; Humans ; Inflammation ; Inflammation - prevention & control ; Male ; Males ; Medical screening ; MicroRNA ; MicroRNAs ; MicroRNAs - blood ; miRNA ; Older people ; Physical fitness ; Physical training ; Plasma ; Proteins ; Range of motion ; Resistance Training ; Senescence ; Strength training ; Tetraspanin 30 - blood ; Tetraspanin 30 - genetics ; Type 2 diabetes ; Weight training ; Young Adult</subject><ispartof>Nutrients, 2021-02, Vol.13 (2), p.665</ispartof><rights>COPYRIGHT 2021 MDPI AG</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-70ec9b9d40d5dc85e66c6bbbe8491e28801ecbc124851c1c292f66ffae38dbb43</citedby><cites>FETCH-LOGICAL-c539t-70ec9b9d40d5dc85e66c6bbbe8491e28801ecbc124851c1c292f66ffae38dbb43</cites><orcidid>0000-0002-9122-8443 ; 0000-0002-0425-8311 ; 0000-0002-4386-9342 ; 0000-0002-4389-1777 ; 0000-0001-5034-9508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33669497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Estébanez, Brisamar</creatorcontrib><creatorcontrib>Visavadiya, Nishant P</creatorcontrib><creatorcontrib>de Paz, José A</creatorcontrib><creatorcontrib>Whitehurst, Michael</creatorcontrib><creatorcontrib>Cuevas, María J</creatorcontrib><creatorcontrib>González-Gallego, Javier</creatorcontrib><creatorcontrib>Huang, Chun-Jung</creatorcontrib><title>Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Aging-associated inflammation is characterized by senescent cell-mediated secretion of high levels of inflammatory mediators, such as microRNA (miR)-146a. Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA.</description><subject>Adaptation</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>CD14 antigen</subject><subject>CD63 antigen</subject><subject>CD81 antigen</subject><subject>CD9 antigen</subject><subject>Cell Communication</subject><subject>Cell signaling</subject><subject>Cell-Free Nucleic Acids - blood</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exosomes - chemistry</subject><subject>Exosomes - physiology</subject><subject>Female</subject><subject>Fitness training programs</subject><subject>Gene Expression - physiology</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Male</subject><subject>Males</subject><subject>Medical screening</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>miRNA</subject><subject>Older people</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Range of motion</subject><subject>Resistance Training</subject><subject>Senescence</subject><subject>Strength training</subject><subject>Tetraspanin 30 - blood</subject><subject>Tetraspanin 30 - genetics</subject><subject>Type 2 diabetes</subject><subject>Weight training</subject><subject>Young Adult</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkttu1DAQhiMEolXpDQ-ALHGDkFJ8TnyDtNotB6lAVZVry3HGu64Se7EToI_AW-OlSw8I-8Jj-5t_PNZfVc8JPmFM4TdhJgxTLKV4VB1S3NBaSs4e34sPquOcr_BuNLiR7Gl1wJiUiqvmsPp1AdnnyQQL6DIZH3xYo5UfS5A3kNG0AXT6c5sgZx8Diq7sYo4joOVKMnSe4gQ-oB9-2sR5Qp9i7523ZtrD54PJo0Gjv6gJl6YWW2RCj6xbfV6gkvdHfughDdfPqifODBmO9-tR9fXd6eXyQ3325f3H5eKstoKpqW4wWNWpnuNe9LYVIKWVXddByxUB2raYgO0sobwVxBJLFXVSOmeAtX3XcXZUvb3R3c7dCL2FMCUz6G3yo0nXOhqvH94Ev9Hr-F03itJGiiLwai-Q4rcZ8qRHny0MgwkQ56wpV63AhNK2oC__Qa_inEJpb0dRQQTG7I5amwG0Dy6WunYnqheloOQcy927T_5DldnD6G0M4Hw5f5Dw-ibBpphzAnfbI8F65x19550Cv7j_K7foX6ew3-mEveI</recordid><startdate>20210219</startdate><enddate>20210219</enddate><creator>Estébanez, Brisamar</creator><creator>Visavadiya, Nishant P</creator><creator>de Paz, José A</creator><creator>Whitehurst, Michael</creator><creator>Cuevas, María J</creator><creator>González-Gallego, Javier</creator><creator>Huang, Chun-Jung</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9122-8443</orcidid><orcidid>https://orcid.org/0000-0002-0425-8311</orcidid><orcidid>https://orcid.org/0000-0002-4386-9342</orcidid><orcidid>https://orcid.org/0000-0002-4389-1777</orcidid><orcidid>https://orcid.org/0000-0001-5034-9508</orcidid></search><sort><creationdate>20210219</creationdate><title>Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly</title><author>Estébanez, Brisamar ; 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Moreover, a rise of circulating cell-free DNA (cfDNA) is also related to systemic inflammation and frailty in the elderly. Exosome-mediated cell-to-cell communication is fundamental in cellular senescence and aging. The plasma changes in exercise-promoted miR-146a-5p, cfDNA, and exosome release could be the key to facilitate intercellular communication and systemic adaptations to exercise in aging. Thirty-eight elderly subjects (28 trained and 10 controls) volunteered in an 8-week resistance training protocol. The levels of plasma miR-146a-5p, cfDNA, and exosome markers (CD9, CD14, CD63, CD81, Flotillin [Flot]-1, and VDAC1) were measured prior to and following training. Results showed no changes in plasma miR-146a-5p and cfDNA levels with training. The levels of exosome markers (Flot-1, CD9, and CD81) as well as exosome-carried proteins (CD14 and VDAC1) remained unchanged, whereas an attenuated CD63 response was found in the trained group compared to the controls. These findings might partially support the anti-inflammatory effect of resistance training in the elderly as evidenced by the diminishment of exosome CD63 protein expression, without modification of plasma miR-146a-5p and cfDNA.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33669497</pmid><doi>10.3390/nu13020665</doi><orcidid>https://orcid.org/0000-0002-9122-8443</orcidid><orcidid>https://orcid.org/0000-0002-0425-8311</orcidid><orcidid>https://orcid.org/0000-0002-4386-9342</orcidid><orcidid>https://orcid.org/0000-0002-4389-1777</orcidid><orcidid>https://orcid.org/0000-0001-5034-9508</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Aged Aged, 80 and over Aging Aging - physiology CD14 antigen CD63 antigen CD81 antigen CD9 antigen Cell Communication Cell signaling Cell-Free Nucleic Acids - blood Deoxyribonucleic acid Diabetes DNA Ethylenediaminetetraacetic acid Exercise Exercise - physiology Exosomes - chemistry Exosomes - physiology Female Fitness training programs Gene Expression - physiology Geriatrics Humans Inflammation Inflammation - prevention & control Male Males Medical screening MicroRNA MicroRNAs MicroRNAs - blood miRNA Older people Physical fitness Physical training Plasma Proteins Range of motion Resistance Training Senescence Strength training Tetraspanin 30 - blood Tetraspanin 30 - genetics Type 2 diabetes Weight training Young Adult |
| title | Resistance Training Diminishes the Expression of Exosome CD63 Protein without Modification of Plasma miR-146a-5p and cfDNA in the Elderly |
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