Instability of the NS1 Glycoprotein from La Reunion 2018 Dengue 2 Virus (Cosmopolitan-1 Genotype) in Huh7 Cells Is Due to Lysine Residues on Positions 272 and 324

La Reunion island in the South West Indian Ocean is now endemic for dengue following the introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2 infection causes a wide spectrum of clinical manifestations ranging from flu-like disease to severe dengue. The nonstructu...

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Veröffentlicht in:	International journal of molecular sciences 2021-02, Vol.22 (4), p.1951
Hauptverfasser:	Ogire, Eva, Diaz, Olivier, Vidalain, Pierre-Olivier, Lotteau, Vincent, Desprès, Philippe, Roche, Marjolaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Antigens, Viral Antigens, Viral - chemistry Antigens, Viral - genetics Cell Line, Tumor Dengue Dengue - epidemiology Dengue - metabolism Dengue - virology Dengue Virus Dengue Virus - metabolism Epidemics Genotype HEK293 Cells Hepatocytes Hepatocytes - metabolism Hepatocytes - virology Humans Life Sciences Lysine Lysine - chemistry Microbiology and Parasitology Protein Multimerization Protein Stability Recombinant Proteins Recombinant Proteins - chemistry Reunion Reunion - epidemiology Serogroup Tanzania Tanzania - epidemiology Transfection Viral Nonstructural Proteins Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Virology
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