Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice

Background: NLR family pyrin domain containing 3 (NLRP3) inflammasome has been implicated in the development of atherosclerosis and several studies have suggested that inhibiting NLRP3 inflammasome could be a potential therapeutic approach to treat atherosclerosis. Baicalin is a flavone glycoside wi...

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Veröffentlicht in:	Diabetes & vascular disease research 2020-11, Vol.17 (6), p.1479164120977441-1479164120977441
Hauptverfasser:	Zhao, Jingfei, Wang, Zhengtang, Yuan, Zhilu, Lv, Shuzhen, Su, Qingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Aorta - drug effects Aorta - metabolism Aorta - pathology Aortic Diseases - metabolism Aortic Diseases - pathology Aortic Diseases - prevention & control Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Disease Models, Animal Flavonoids - pharmacology Inflammasomes - antagonists & inhibitors Inflammasomes - genetics Inflammasomes - metabolism Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Interleukin-1 - metabolism Interleukin-18 - metabolism Male Mice, Inbred C57BL Mice, Knockout, ApoE NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Original Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Signal Transduction Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism
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