NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection

Congenital human cytomegalovirus (cHCMV) infection of the brain is associated with a wide range of neurocognitive sequelae. Using infection of newborn mice with mouse cytomegalovirus (MCMV) as a reliable model that recapitulates many aspects of cHCMV infection, including disseminated infection, CNS...

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Veröffentlicht in:	The Journal of experimental medicine 2021-05, Vol.218 (5)
Hauptverfasser:	Kveštak, Daria, Juranić Lisnić, Vanda, Lisnić, Berislav, Tomac, Jelena, Golemac, Mijo, Brizić, Ilija, Indenbirken, Daniela, Cokarić Brdovčak, Maja, Bernardini, Giovanni, Krstanović, Fran, Rožmanić, Carmen, Grundhoff, Adam, Krmpotić, Astrid, Britt, William J, Jonjić, Stipan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Brain - immunology Brain - pathology Brain - virology Brief Definitive Report Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Chemokine CXCL10 - metabolism Chemokine CXCL9 - genetics Chemokine CXCL9 - immunology Chemokine CXCL9 - metabolism Cytomegalovirus - immunology Cytomegalovirus - physiology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology Gene Expression Regulation - immunology Humans Immunity, Innate - immunology Infectious Disease and Host Defense Inflammation - genetics Inflammation - immunology Inflammation - virology Innate Immunity and Inflammation Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocytes - immunology Lymphocytes - metabolism Mice Mice, 129 Strain Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microglia - immunology Microglia - metabolism Microglia - virology Neuroinflammation Receptors, CXCR3 - genetics Receptors, CXCR3 - immunology Receptors, CXCR3 - metabolism
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