ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation

Matrix stiffness is a central regulator of fibroblast function. However, the transcriptional mechanisms linking matrix stiffness to changes in fibroblast phenotype are incompletely understood. Here, we evaluated the effect of matrix stiffness on genome-wide chromatin accessibility in freshly isolate...

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Veröffentlicht in:	The Journal of cell biology 2021-05, Vol.220 (5), p.1
Hauptverfasser:	Jones, Dakota L, Meridew, Jeffrey A, Link, Patrick A, Ducharme, Merrick T, Lydon, Katherine L, Choi, Kyoung M, Caporarello, Nunzia, Tan, Qi, Diaz Espinosa, Ana Maria, Xiong, Yuning, Lee, Jeong-Heon, Ye, Zhenqing, Yan, Huihuang, Ordog, Tamas, Ligresti, Giovanni, Varelas, Xaralabos, Tschumperlin, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility Animals Cell Proliferation - genetics Cells, Cultured Chromatin Chromatin - genetics Chromatin or Epigenetics Contractility Cytoskeleton Disease Extracellular matrix Extracellular Matrix - genetics Fibroblasts Fibroblasts - physiology Fibrosis Fibrosis - genetics Gene Expression Regulation - genetics Genome - genetics Genomes Genomics Lung - physiology Mice Mice, Transgenic Occupancy Phenotype Phenotypes Physiology Stiffness Transcription activation Transcription, Genetic - genetics
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