CRISPR/Cas9 Mediated Knock Down of δ-ENaC Blunted the TNF-Induced Activation of ENaC in A549 Cells

Tumor necrosis factor (TNF) is known to activate the epithelial Na channel (ENaC) in A549 cells. A549 cells are widely used model for ENaC research. The role of δ-ENaC subunit in TNF-induced activation has not been studied. In this study we hypothesized that δ-ENaC plays a major role in TNF-induced...

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Veröffentlicht in:	International journal of molecular sciences 2021-02, Vol.22 (4), p.1858
Hauptverfasser:	Shabbir, Waheed, Topcagic, Nermina, Aufy, Mohammed, Oz, Murat
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells CRISPR-Cas Systems Epithelial Sodium Channels - genetics Epithelial Sodium Channels - metabolism Humans Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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