LY6E impairs coronavirus fusion and confers immune control of viral disease

Zoonotic coronaviruses (CoVs) are substantial threats to global health, as exemplified by the emergence of two severe acute respiratory syndrome CoVs (SARS-CoV and SARS-CoV-2) and Middle East respiratory syndrome CoV (MERS-CoV) within two decades 1 – 3 . Host immune responses to CoVs are complex and...

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Veröffentlicht in:	Nature microbiology 2020-11, Vol.5 (11), p.1330-1339
Hauptverfasser:	Pfaender, Stephanie, Mar, Katrina B., Michailidis, Eleftherios, Kratzel, Annika, Boys, Ian N., V’kovski, Philip, Fan, Wenchun, Kelly, Jenna N., Hirt, Dagny, Ebert, Nadine, Stalder, Hanspeter, Kleine-Weber, Hannah, Hoffmann, Markus, Hoffmann, Hans-Heinrich, Saeed, Mohsan, Dijkman, Ronald, Steinmann, Eike, Wight-Carter, Mary, McDougal, Matthew B., Hanners, Natasha W., Pöhlmann, Stefan, Gallagher, Tom, Todt, Daniel, Zimmer, Gert, Rice, Charles M., Schoggins, John W., Thiel, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262 631/326/596/2555 631/326/596/2556 631/326/596/4130 692/699/255/2514 Angiotensin-Converting Enzyme 2 Animals Antigens Antigens, Surface - genetics Antigens, Surface - immunology Antigens, Surface - metabolism Betacoronavirus - immunology Betacoronavirus - physiology Biomedical and Life Sciences Coronaviridae Coronavirus - immunology Coronavirus - physiology Coronavirus Infections - immunology Coronavirus Infections - virology Coronaviruses COVID-19 Dendritic cells Female Fusion protein GPI-Linked Proteins - genetics GPI-Linked Proteins - immunology GPI-Linked Proteins - metabolism Hepatitis Infections Infectious Diseases Interferon Letter Life Sciences Liver diseases Lymphocytes B Male Medical Microbiology Membrane fusion Membrane proteins Mice Mice, Inbred C57BL Mice, Knockout Microbiology Middle East respiratory syndrome Middle East Respiratory Syndrome Coronavirus - immunology Middle East Respiratory Syndrome Coronavirus - physiology Pandemics Parasitology Pathogenesis Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - immunology Pneumonia, Viral - virology Public health Respiratory diseases SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus - immunology Severe acute respiratory syndrome-related coronavirus - physiology Spike protein Spleen Viral diseases Virology Virus Internalization Zoonoses
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