Comparison of Antiviral Activity of Gemcitabine with 2'-Fluoro-2'-Deoxycytidine and Combination Therapy with Remdesivir against SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. The virus still spreads globally through human-to-human transmission. Nevertheless, there are no specific treatments clinically approved. This study aimed to compa...

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Veröffentlicht in:	International journal of molecular sciences 2021-02, Vol.22 (4), p.1581
Hauptverfasser:	Jang, Yejin, Shin, Jin Soo, Lee, Myoung Kyu, Jung, Eunhye, An, Timothy, Kim, Uk-Il, Kim, Kyungjin, Kim, Meehyein
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - pharmacology Alanine - analogs & derivatives Alanine - pharmacology Animals Antiviral activity Antiviral agents Antiviral Agents - pharmacology Antiviral drugs Cell Line Chlorocebus aethiops Combination therapy Coronaviridae Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - metabolism COVID-19 - virology Cytotoxicity Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxyribonucleic acid Disease transmission DNA Drug development Drug dosages Drug Therapy, Combination Epithelial cells Fluorescence Gemcitabine Genomes Humans Infections Influenza Inhibitory Concentration 50 Middle East respiratory syndrome Mortality Polymerase chain reaction Proteins Respiratory diseases RNA polymerase SARS-CoV-2 - drug effects SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Synergistic effect Vero Cells Viral infections Virus Replication - drug effects Viruses
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