Increasing cancer risk over calendar year in people with multiple sclerosis: a case–control study
Background Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice R...
Gespeichert in:
| Veröffentlicht in: | Journal of neurology 2021-03, Vol.268 (3), p.817-824 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 824 |
|---|---|
| container_issue | 3 |
| container_start_page | 817 |
| container_title | Journal of neurology |
| container_volume | 268 |
| creator | Zecca, Chiara Disanto, Giulio Sacco, Rosaria MacLachlan, Sharon Kuhle, Jens Ramagopalan, Sreeram V. Gobbi, Claudio |
| description | Background
Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients.
Methods
Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS patients and 39,448 controls matched by sex, age, general practitioner, and registration year. Cancer rates were compared using multivariable Cox regression models. Ethics approval was not required.
Results
Cancer was reported in 433 (4.41%) MS patients and 2014 (5.31%) controls after index date. Cancer risk was associated with gender (HR for female = 0.88, 95% CI = 0.81–0.96,
p
= 0.004), age at index date (HR = 1.06, 95% CI = 1.06–1.07,
p
|
| doi_str_mv | 10.1007/s00415-020-10170-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7914231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2493882377</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-8ec594910151d8d6c3b59a0ecde14d9b006bf2adcd152d04dd9e43dbbab40d663</originalsourceid><addsrcrecordid>eNp9kUtuFDEQhi0EIkPgAiyQJTZsGsqv6TYLpCjiESkSG1hbbrtm4uCxB7s7aHa5Q27ISfAwITwWbOyy66vfVf4JecrgJQPoX1UAyVQHHDoGrIdO3SMLJgXvmFT6PlmAkO1SKHlEHtV6CQBDSzwkR0K0SAu9IO4suYK2hrSmziaHhZZQv9B81SJnIyZvC91hW0KiW8zbiPRbmC7oZo5T2J-qi1hyDfU1ta2k4vfrG5fTVHKkdZr97jF5sLKx4pPb_Zh8fvf20-mH7vzj-7PTk_POyV5O3YBOaanbKIr5wS-dGJW2gM4jk16PAMtxxa13ninuQXqvUQo_jnaU4JdLcUzeHHS387hB77D1YKPZlrCxZWeyDebvTAoXZp2vTK-Z5II1gRe3AiV_nbFOZhOqwxhtwjxXw6XiutdC9Q19_g96meeS2niN0mIYuOj3FD9Qrn1QLbi6a4aB2XtoDh6a5qH56aFRrejZn2PclfwyrQHiANSWSmssv9_-j-wPZ9aqfQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2493882377</pqid></control><display><type>article</type><title>Increasing cancer risk over calendar year in people with multiple sclerosis: a case–control study</title><source>Springer Nature - Complete Springer Journals</source><creator>Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio</creator><creatorcontrib>Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio</creatorcontrib><description>Background
Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients.
Methods
Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS patients and 39,448 controls matched by sex, age, general practitioner, and registration year. Cancer rates were compared using multivariable Cox regression models. Ethics approval was not required.
Results
Cancer was reported in 433 (4.41%) MS patients and 2014 (5.31%) controls after index date. Cancer risk was associated with gender (HR for female = 0.88, 95% CI = 0.81–0.96,
p
= 0.004), age at index date (HR = 1.06, 95% CI = 1.06–1.07,
p
< 0.001), and index year (HR = 1.01, 95% CI = 1.00–1.02,
p
= 0.016), but not with MS status (HR = 0.95, 95% CI = 0.86–1.05,
p
= 0.323). A significant interaction between MS status and index year was found (HR = 1.02, 95% CI = 1.00–1.04,
p
= 0.022). Cancer risk was positively associated with index year among MS patients (HR = 1.03, 95% CI = 1.01–1.05;
p
= 0.010), but not controls (HR = 1.01, 95% CI = 0.99–1.02;
p
= 0.144). MS patients compared to controls had no increased risk for any specific cancer type.
Conclusions
Overall cancer risk was similar in multiple sclerosis patients and matched controls. The frequency of cancer diagnoses has increased over time among MS patients but not in controls.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-020-10170-5</identifier><identifier>PMID: 33084939</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Regression analysis</subject><ispartof>Journal of neurology, 2021-03, Vol.268 (3), p.817-824</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-8ec594910151d8d6c3b59a0ecde14d9b006bf2adcd152d04dd9e43dbbab40d663</citedby><cites>FETCH-LOGICAL-c474t-8ec594910151d8d6c3b59a0ecde14d9b006bf2adcd152d04dd9e43dbbab40d663</cites><orcidid>0000-0002-7554-0664 ; 0000-0002-8512-6096 ; 0000-0002-4766-5160 ; 0000-0002-9990-3431 ; 0000-0002-6623-4649 ; 0000-0002-6963-8892</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-020-10170-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-020-10170-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33084939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zecca, Chiara</creatorcontrib><creatorcontrib>Disanto, Giulio</creatorcontrib><creatorcontrib>Sacco, Rosaria</creatorcontrib><creatorcontrib>MacLachlan, Sharon</creatorcontrib><creatorcontrib>Kuhle, Jens</creatorcontrib><creatorcontrib>Ramagopalan, Sreeram V.</creatorcontrib><creatorcontrib>Gobbi, Claudio</creatorcontrib><title>Increasing cancer risk over calendar year in people with multiple sclerosis: a case–control study</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients.
Methods
Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS patients and 39,448 controls matched by sex, age, general practitioner, and registration year. Cancer rates were compared using multivariable Cox regression models. Ethics approval was not required.
Results
Cancer was reported in 433 (4.41%) MS patients and 2014 (5.31%) controls after index date. Cancer risk was associated with gender (HR for female = 0.88, 95% CI = 0.81–0.96,
p
= 0.004), age at index date (HR = 1.06, 95% CI = 1.06–1.07,
p
< 0.001), and index year (HR = 1.01, 95% CI = 1.00–1.02,
p
= 0.016), but not with MS status (HR = 0.95, 95% CI = 0.86–1.05,
p
= 0.323). A significant interaction between MS status and index year was found (HR = 1.02, 95% CI = 1.00–1.04,
p
= 0.022). Cancer risk was positively associated with index year among MS patients (HR = 1.03, 95% CI = 1.01–1.05;
p
= 0.010), but not controls (HR = 1.01, 95% CI = 0.99–1.02;
p
= 0.144). MS patients compared to controls had no increased risk for any specific cancer type.
Conclusions
Overall cancer risk was similar in multiple sclerosis patients and matched controls. The frequency of cancer diagnoses has increased over time among MS patients but not in controls.</description><subject>Cancer</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Regression analysis</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtuFDEQhi0EIkPgAiyQJTZsGsqv6TYLpCjiESkSG1hbbrtm4uCxB7s7aHa5Q27ISfAwITwWbOyy66vfVf4JecrgJQPoX1UAyVQHHDoGrIdO3SMLJgXvmFT6PlmAkO1SKHlEHtV6CQBDSzwkR0K0SAu9IO4suYK2hrSmziaHhZZQv9B81SJnIyZvC91hW0KiW8zbiPRbmC7oZo5T2J-qi1hyDfU1ta2k4vfrG5fTVHKkdZr97jF5sLKx4pPb_Zh8fvf20-mH7vzj-7PTk_POyV5O3YBOaanbKIr5wS-dGJW2gM4jk16PAMtxxa13ninuQXqvUQo_jnaU4JdLcUzeHHS387hB77D1YKPZlrCxZWeyDebvTAoXZp2vTK-Z5II1gRe3AiV_nbFOZhOqwxhtwjxXw6XiutdC9Q19_g96meeS2niN0mIYuOj3FD9Qrn1QLbi6a4aB2XtoDh6a5qH56aFRrejZn2PclfwyrQHiANSWSmssv9_-j-wPZ9aqfQ</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Zecca, Chiara</creator><creator>Disanto, Giulio</creator><creator>Sacco, Rosaria</creator><creator>MacLachlan, Sharon</creator><creator>Kuhle, Jens</creator><creator>Ramagopalan, Sreeram V.</creator><creator>Gobbi, Claudio</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7554-0664</orcidid><orcidid>https://orcid.org/0000-0002-8512-6096</orcidid><orcidid>https://orcid.org/0000-0002-4766-5160</orcidid><orcidid>https://orcid.org/0000-0002-9990-3431</orcidid><orcidid>https://orcid.org/0000-0002-6623-4649</orcidid><orcidid>https://orcid.org/0000-0002-6963-8892</orcidid></search><sort><creationdate>20210301</creationdate><title>Increasing cancer risk over calendar year in people with multiple sclerosis: a case–control study</title><author>Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-8ec594910151d8d6c3b59a0ecde14d9b006bf2adcd152d04dd9e43dbbab40d663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zecca, Chiara</creatorcontrib><creatorcontrib>Disanto, Giulio</creatorcontrib><creatorcontrib>Sacco, Rosaria</creatorcontrib><creatorcontrib>MacLachlan, Sharon</creatorcontrib><creatorcontrib>Kuhle, Jens</creatorcontrib><creatorcontrib>Ramagopalan, Sreeram V.</creatorcontrib><creatorcontrib>Gobbi, Claudio</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zecca, Chiara</au><au>Disanto, Giulio</au><au>Sacco, Rosaria</au><au>MacLachlan, Sharon</au><au>Kuhle, Jens</au><au>Ramagopalan, Sreeram V.</au><au>Gobbi, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing cancer risk over calendar year in people with multiple sclerosis: a case–control study</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>268</volume><issue>3</issue><spage>817</spage><epage>824</epage><pages>817-824</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background
Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients.
Methods
Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS patients and 39,448 controls matched by sex, age, general practitioner, and registration year. Cancer rates were compared using multivariable Cox regression models. Ethics approval was not required.
Results
Cancer was reported in 433 (4.41%) MS patients and 2014 (5.31%) controls after index date. Cancer risk was associated with gender (HR for female = 0.88, 95% CI = 0.81–0.96,
p
= 0.004), age at index date (HR = 1.06, 95% CI = 1.06–1.07,
p
< 0.001), and index year (HR = 1.01, 95% CI = 1.00–1.02,
p
= 0.016), but not with MS status (HR = 0.95, 95% CI = 0.86–1.05,
p
= 0.323). A significant interaction between MS status and index year was found (HR = 1.02, 95% CI = 1.00–1.04,
p
= 0.022). Cancer risk was positively associated with index year among MS patients (HR = 1.03, 95% CI = 1.01–1.05;
p
= 0.010), but not controls (HR = 1.01, 95% CI = 0.99–1.02;
p
= 0.144). MS patients compared to controls had no increased risk for any specific cancer type.
Conclusions
Overall cancer risk was similar in multiple sclerosis patients and matched controls. The frequency of cancer diagnoses has increased over time among MS patients but not in controls.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33084939</pmid><doi>10.1007/s00415-020-10170-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7554-0664</orcidid><orcidid>https://orcid.org/0000-0002-8512-6096</orcidid><orcidid>https://orcid.org/0000-0002-4766-5160</orcidid><orcidid>https://orcid.org/0000-0002-9990-3431</orcidid><orcidid>https://orcid.org/0000-0002-6623-4649</orcidid><orcidid>https://orcid.org/0000-0002-6963-8892</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5354 |
| ispartof | Journal of neurology, 2021-03, Vol.268 (3), p.817-824 |
| issn | 0340-5354 1432-1459 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7914231 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer Medical diagnosis Medicine Medicine & Public Health Multiple sclerosis Neurology Neuroradiology Neurosciences Original Communication Regression analysis |
| title | Increasing cancer risk over calendar year in people with multiple sclerosis: a case–control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A44%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increasing%20cancer%20risk%20over%20calendar%20year%20in%20people%20with%20multiple%20sclerosis:%20a%20case%E2%80%93control%20study&rft.jtitle=Journal%20of%20neurology&rft.au=Zecca,%20Chiara&rft.date=2021-03-01&rft.volume=268&rft.issue=3&rft.spage=817&rft.epage=824&rft.pages=817-824&rft.issn=0340-5354&rft.eissn=1432-1459&rft_id=info:doi/10.1007/s00415-020-10170-5&rft_dat=%3Cproquest_pubme%3E2493882377%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2493882377&rft_id=info:pmid/33084939&rfr_iscdi=true |