Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis

Fungi of the order Mucorales cause mucormycosis, a lethal infection with an incompletely understood pathogenesis. We demonstrate that Mucorales fungi produce a toxin, which plays a central role in virulence. Polyclonal antibodies against this toxin inhibit its ability to damage human cells in vitro...

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Veröffentlicht in:	Nature microbiology 2021-03, Vol.6 (3), p.313-326
Hauptverfasser:	Soliman, Sameh S. M., Baldin, Clara, Gu, Yiyou, Singh, Shakti, Gebremariam, Teclegiorgis, Swidergall, Marc, Alqarihi, Abdullah, Youssef, Eman G., Alkhazraji, Sondus, Pikoulas, Antonis, Perske, Christina, Venkataramani, Vivek, Rich, Abigail, Bruno, Vincent M., Hotopp, Julie Dunning, Mantis, Nicolas J., Edwards, John E., Filler, Scott G., Chamilos, Georgios, Vitetta, Ellen S., Ibrahim, Ashraf S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/193/2542 692/420/254 Animals Antitoxins - immunology Antitoxins - pharmacology Antitoxins - therapeutic use Apoptosis Biomedical and Life Sciences Capillary Permeability Cells, Cultured Cross Reactions Fungi Humans Hyphae - chemistry Hyphae - pathogenicity Infectious Diseases Lectins - metabolism Life Sciences Medical Microbiology Mice Microbiology Mucorales Mucorales - chemistry Mucorales - classification Mucorales - genetics Mucorales - pathogenicity Mucormycosis Mucormycosis - microbiology Mucormycosis - pathology Mucormycosis - prevention & control Mycotoxins - chemistry Mycotoxins - genetics Mycotoxins - immunology Mycotoxins - metabolism N-Glycosylase Necrosis Parasitology Pathogenesis Permeability Polyclonal antibodies Protein biosynthesis Rhizopus - chemistry Rhizopus - genetics Rhizopus - pathogenicity Ribosome Inactivating Proteins - metabolism Ricin Ricin - chemistry Ricin - immunology Ricin - metabolism RNA Interference RNA-mediated interference Structure-function relationships Therapeutic applications Therapeutic targets Virology Virulence Virulence - drug effects Virulence - genetics
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