Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model

Dl-3-n-butylphthalide (NBP) has been widely used to treat ischemic stroke in China. To investigate the mechanisms underlying NBP activity, we established a permanent middle cerebral artery occlusion (pMCAO) rat model and injected the rats with 4 mg/kg/d NBP for nine days. We then assessed neuroinfla...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2021-02, Vol.13 (3), p.3763-3778
Hauptverfasser:	Liu, Xi, Liu, Runzhe, Fu, Dongxu, Wu, Hao, Zhao, Xin, Sun, Yi, Wang, Meng, Pu, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzofurans - pharmacology Brain - drug effects Brain - metabolism Brain - pathology Caspase 1 - drug effects Caspase 1 - metabolism Cyclic AMP Response Element-Binding Protein - drug effects Cyclic AMP Response Element-Binding Protein - metabolism Forkhead Transcription Factors - drug effects Forkhead Transcription Factors - metabolism Infarction, Middle Cerebral Artery Inflammation - metabolism Ischemic Stroke - metabolism Ischemic Stroke - pathology Ischemic Stroke - physiopathology Ki-67 Antigen - drug effects Ki-67 Antigen - metabolism Molecular Docking Simulation Neovascularization, Physiologic - drug effects Nerve Regeneration - drug effects Neuroprotective Agents - pharmacology NLR Family, Pyrin Domain-Containing 3 Protein - drug effects NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Phospholipids - metabolism Rats Research Paper Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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