The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis

Zinc has been known to be essential for cell division for over 40 years but the molecular pathways involved remain elusive. Cellular zinc import across biological membranes necessitates the help of zinc transporters such as the SLC39A family of ZIP transporters. We have discovered a molecular proces...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-02, Vol.78 (4), p.1781-1798
Hauptverfasser:	Nimmanon, Thirayost, Ziliotto, Silvia, Ogle, Olivia, Burt, Anna, Gee, Julia M. W., Andrews, Glen K., Kille, Pete, Hogstrand, Christer, Maret, Wolfgang, Taylor, Kathryn M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biochemistry Biological membranes Biomedical and Life Sciences Biomedicine Carrier Proteins - genetics Cation Transport Proteins - genetics Cell Biology Cell cycle Cell division Gene Expression Regulation Humans Life Sciences MCF-7 Cells Mitosis Mitosis - genetics Original Original Article Phosphorylation Phosphorylation - genetics Protein Multimerization - genetics Signal Transduction - genetics Stat3 protein STAT3 Transcription Factor - genetics Zinc Zinc - chemistry Zinc - metabolism
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