The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals

The Organisation for Economic Co-Operation and Development Test Guideline 488 (TG 488) uses transgenic rodent models to generate in vivo mutagenesis data for regulatory submission. The recommended design in TG 488, 28 consecutive daily exposures with tissue sampling three days later (28 + 3d), is op...

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Veröffentlicht in:	Archives of toxicology 2021-03, Vol.95 (3), p.1103-1116
Hauptverfasser:	Marchetti, Francesco, Zhou, Gu, LeBlanc, Danielle, White, Paul A., Williams, Andrew, Yauk, Carole L., Douglas, George R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animal tissues Animals Benzo(a)pyrene Biomedical and Life Sciences Biomedicine Bone marrow Confidence intervals Dose-Response Relationship, Drug Environmental Health Exposure Genotoxicity and Carcinogenicity Germ cells Germ Cells - drug effects Hepatocytes In vivo methods and tests Male Mice Mice, Transgenic Mutagenesis Mutagenesis - drug effects Mutagenicity Tests - methods Mutagens Mutagens - administration & dosage Mutagens - toxicity Mutants Mutation Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Procarbazine Pyrene Sampling Time Factors
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