Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts

•Long OPA1 are retained in H9c2 cells under CCCP challenge, despite presence of OMA1.•Differentiation of H9c2s robustly and reversibly activates OPA1 cleavage.•Induction of OPA1 processing suggests novel mechanistic and developmental OPA1 roles. Optic atrophy-1 (OPA1) is a dynamin-like GTPase locali...

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Veröffentlicht in:	Mitochondrion 2021-03, Vol.57, p.88-96
Hauptverfasser:	Garcia, Iraselia, Calderon, Fredy, la Torre, Patrick De, Vallier, Shaynah St, Rodriguez, Cristobal, Agarwala, Divya, Keniry, Megan, Innis-Whitehouse, Wendy, Gilkerson, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cardiac Cell Differentiation Cell Line, Tumor Cultured cell Differentiation GTP Phosphohydrolases - metabolism Humans Membrane Potentials Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Mice Mitochondria Mitochondria, Heart - metabolism Mitochondrial Membranes - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism OMA1 OPA1 Rats Tretinoin - pharmacology
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